AMPK and the Adaptation to Exercise.

AMPK and the Adaptation to Exercise.
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AMPK和适应运动。

DOI:
10.1146/annurev-physiol-060721-095517
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发表时间:
2022-02-10
影响因子:
18.2
通讯作者:
Yan Z
Yan Z
中科院分区:
医学1区
文献类型:
--
作者:
Spaulding HR;Yan Z

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非传染性疾病是导致全世界死亡的慢性疾病,但这些疾病可以通过定期锻炼来预防和减轻。运动激活信号分子和转录网络,以促进生理适应,如纤维类型转化,血管生成和线粒体生物合成。AMP活化蛋白激酶(AMPK)是感知能量状态、促进葡萄糖和脂肪酸利用的代谢并介导许多重要组织和器官中的有益细胞适应的主要调节剂。本文综述了运动诱导AMPK激活在调节系统代谢和促进健康益处中的作用。
Noncommunicable diseases are chronic diseases that contribute to death worldwide, but these diseases can be prevented and mitigated with regular exercise. Exercise activates signaling molecules and the transcriptional network to promote physiological adaptations, such as fiber type transformation, angiogenesis, and mitochondrial biogenesis. AMP-activated protein kinase (AMPK) is a master regulator that senses the energy state, promotes metabolism for glucose and fatty acid utilization, and mediates beneficial cellular adaptations in many vital tissues and organs. This review focuses on the current, integrative understanding of the role of exercise-induced activation of AMPK in the regulation of system metabolism and promotion of health benefits.
DOI: 10.3389/fphys.2015.00085
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