Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans.
Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans.
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DOI：
10.3390/genes8010015
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发表时间：
2017-01-05
期刊：
影响因子：
3.5
通讯作者：
Federle MJ
中科院分区：
文献类型：
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作者：
Shanker E;Federle MJ
人类病原体肺炎链球菌和变形链球菌都进化出了复杂的群体感应（QS）系统，该系统调节细菌素的产生和进入能力状态，这是自然转化的必要条件。自然转化为细菌提供了一种修复受损基因的机制或作为新的有利性状的来源。在肺炎链球菌中，能力通路由双组分信号转导通路ComCDE控制，ComCDE直接调控SigX， SigX是进入能力所需的替代sigma因子。在过去的二十年中，细胞杀伤效应物（即杀兄弟剂）已被认为是肺炎球菌能力QS途径的重要靶点。最近，ComCDE和平行的BlpRH通路之间的直接相互作用被发现，调节细菌素的产生，进一步加强了这两个QS系统之间的相互联系。有趣的是，在龋齿的主要病原体变形链球菌中也发现了类似的主题。本文比较了肺炎链球菌和变形链球菌中细菌素与能力QS通路之间的关系，希望为整个链球菌属的调控通路提供线索，作为有效研究不可转化链球菌中假定的能力通路的潜在工具。
The human pathogens Streptococcus pneumoniae and Streptococcus mutans have both evolved complex quorum sensing (QS) systems that regulate the production of bacteriocins and the entry into the competent state, a requirement for natural transformation. Natural transformation provides bacteria with a mechanism to repair damaged genes or as a source of new advantageous traits. In S. pneumoniae, the competence pathway is controlled by the two-component signal transduction pathway ComCDE, which directly regulates SigX, the alternative sigma factor required for the initiation into competence. Over the past two decades, effectors of cellular killing (i.e., fratricides) have been recognized as important targets of the pneumococcal competence QS pathway. Recently, direct interactions between the ComCDE and the paralogous BlpRH pathway, regulating bacteriocin production, were identified, further strengthening the interconnections between these two QS systems. Interestingly, a similar theme is being revealed in S. mutans, the primary etiological agent of dental caries. This review compares the relationship between the bacteriocin and the competence QS pathways in both S. pneumoniae and S. mutans, and hopes to provide clues to regulatory pathways across the genus Streptococcus as a potential tool to efficiently investigate putative competence pathways in nontransformable streptococci.