The DF-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses
The DF-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses
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DOI：
10.1006/viro.1998.9290
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发表时间：
1998-09-01
期刊：
影响因子：
3.7
通讯作者：
Vogt, PK
中科院分区：
文献类型：
--
作者：
Himly, M;Foster, DN;Vogt, PK
DF-1是鸡胚成纤维细胞的连续细胞系。细胞不含与禽肉瘤和白血病病毒相关的内源性序列，并具有正常的成纤维细胞形态。DF-1细胞支持禽类逆转录病毒的复制;不同的致癌基因在DF-1单层上诱导致癌转化灶，包膜亚群B、D和C的禽类白血病病毒诱导细胞死亡并形成噬斑。这一新的细胞系将极大地促进禽流感病毒致癌转化和细胞杀伤的研究。(C)北京：科学出版社.
DF-1 is a continuous cell line of chicken embryo fibroblasts. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transformation on monolayers of DF-1, and avian leukosis viruses of envelope subgroups B, D, and C induce cell death and form plaques. The new cell line will greatly facilitate studies on oncogenic transformation and cell killing by avian viruses. (C) 1998 Academic Press.