Target-selective GABAergic control of entorhinal cortex output
Target-selective GABAergic control of entorhinal cortex output
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DOI：
10.1038/nn.2570
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发表时间：
2010-07-01
影响因子：
25
通讯作者：
Soltesz, Ivan
中科院分区：
文献类型：
--
作者：
Varga, Csaba;Lee, Soo Yeun;Soltesz, Ivan
内侧内嗅皮层（MEC）是空间导航和记忆的主要中枢。我们发现，表达大麻素1型受体的gabaergybasket细胞选择性地支配大鼠MEC第二层的主要细胞，这些细胞投射到海马外，但避开了邻近的细胞，这些细胞形成了通往齿状回的穿孔通路。这些结果表明gaba能微电路的组织反映了主神经元的远距离轴突目标。
The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.