Immune-Based Approaches for the Treatment of Pediatric Malignancies.
Immune-Based Approaches for the Treatment of Pediatric Malignancies.
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DOI：
10.1146/annurev-cancerbio-030419-033436
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发表时间：
2020-03
影响因子：
7.7
通讯作者：
Maris JM
中科院分区：
文献类型：
--
作者：
Bosse KR;Majzner RG;Mackall CL;Maris JM
嵌合抗原受体（CAR） T细胞治疗儿童B细胞急性淋巴细胞白血病（ALL）具有强大的疗效，免疫疗法现已被批准用于儿科癌症，为患有先前致命疾病的儿童提供了治愈的机会，并可能提供更有针对性的治疗，以限制治疗相关的发病率。大多数儿童癌症的发育起源使其成为免疫疗法的理想靶点，这些免疫疗法利用了谱系特异性细胞表面分子（如抗体、抗体-药物偶联物或CAR - T细胞）的差异表达，而其他依赖于肿瘤免疫原性的疗法（如免疫检查点抑制剂）的疗效迄今为止受到限制。在此，我们回顾了儿童癌症免疫治疗的现状，讨论了针对这些疾病开发免疫治疗的挑战，并概述了儿童免疫治疗发现和发展的未来方向。
Immune-based therapies have now been credentialed for pediatric cancers with the robust efficacy of chimeric antigen receptor (CAR) T cells for pediatric B cell acute lymphocytic leukemia (ALL), offering a chance of a cure for children with previously lethal disease and a potentially more targeted therapy to limit treatment-related morbidities. The developmental origins of most pediatric cancers make them ideal targets for immune-based therapies that capitalize on the differential expression of lineage-specific cell surface molecules such as antibodies, antibody-drug conjugates, or CAR T cells, while the efficacy of other therapies that depend on tumor immunogenicity such as immune checkpoint inhibitors has been limited to date. Here we review the current status of immune-based therapies for childhood cancers, discuss challenges to developing immunotherapeutics for these diseases, and outline future directions of pediatric immunotherapy discovery and development.
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影响因子：
28.2
作者：
D'Angelo SP;Melchiori L;Merchant MS;Bernstein D;Glod J;Kaplan R;Grupp S;Tap WD;Chagin K;Binder GK;Basu S;Lowther DE;Wang R;Bath N;Tipping A;Betts G;Ramachandran I;Navenot JM;Zhang H;Wells DK;Van Winkle E;Kari G;Trivedi T;Holdich T;Pandite L;Amado R;Mackall CL
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Rheingold SR
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5.3
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45.3
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通讯作者：
Gottschalk, Stephen
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5.3
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通讯作者：
Dimitrov, Dimiter S.