Genome-wide changes in genetic diversity in a population of Myotis lucifugus affected by white-nose syndrome
Genome-wide changes in genetic diversity in a population of Myotis lucifugus affected by white-nose syndrome
复制标题
受白鼻综合征影响的荧光鼠群体遗传多样性的全基因组变化
DOI：
10.1101/764647
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Lilley T
中科院分区：
文献类型：
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作者：
Lilley T
新的病原体可导致种群数量大幅下降，甚至导致宿主灭绝。但疾病也可以作为对幸存者的选择性压力，推动耐药性或耐受性的演变。蝙蝠白鼻症(WNS)是一种在北美迅速传播的野生动物疾病。引起这种疾病的真菌侵入冬眠蝙蝠的皮肤组织，导致冬眠行为中断，过早耗尽能量，并随后死亡。我们使用全基因组测序来研究北美东部的一个种群中的等位基因频率的变化，以寻找对WNS的遗传抗性。我们的结果显示，随着时间的推移，人群中的FST值较低，即在WNS之前(WNS前)与WNS存活的人群(WNS后)相比。然而，当宾夕法尼亚州和纽约州之间的地理界限划分人口时，支架GL429776上的价值在后WNS样本中明显增加。分叉区域中存在的基因与体温调节和促进棕色脂肪的产生有关。因此，尽管WNS可能没有受到整个M的影响。由于萤火虫种群面临选择压力，它可能通过减少种群内的基因流而为宾夕法尼亚州的特定等位基因进行选择。然而，在WNS之后，残存的亚群的持续存在可能是由于蝙蝠生活史中的多种因素。
Novel pathogens can cause massive declines in populations, and even extirpation of hosts. But disease can also act as a selective pressure on survivors, driving the evolution of resistance or tolerance. Bat white-nose syndrome (WNS) is a rapidly spreading wildlife disease in North America. The fungus causing the disease invades skin tissues of hibernating bats, resulting in disruption of hibernation behavior, premature energy depletion, and subsequent death. We used whole-genome sequencing to investigate changes in allele frequencies within a population ofMyotis lucifugusin eastern North America to search for genetic resistance to WNS. Our results show low FSTvalues within the population across time,i.e., prior to WNS (Pre-WNS) compared to the population that has survived WNS (Post-WNS). However, when dividing the population with a geographical cut-off between the states of Pennsylvania and New York, a sharp increase in values on scaffold GL429776 is evident in the Post-WNS samples. Genes present in the diverged area are associated with thermoregulation and promotion of brown fat production. Thus, although WNS may not have subjected the entireM. lucifuguspopulation to selective pressure, it may have selected for specific alleles in Pennsylvania through decreased gene flow within the population. However, the persistence of remnant sub-populations in the aftermath of WNS is likely due to multiple factors in bat life history.