POLYNEUROPATHY COMPLICATING BONE-MARROW AND SOLID-ORGAN TRANSPLANTATION
POLYNEUROPATHY COMPLICATING BONE-MARROW AND SOLID-ORGAN TRANSPLANTATION
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DOI：
10.1212/wnl.43.8.1513
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发表时间：
1993-08-01
期刊：
影响因子：
9.9
通讯作者：
MENDELL, JR
中科院分区：
文献类型：
--
作者：
AMATO, AA;BAROHN, RJ;MENDELL, JR
我们报告了一个广泛性多发性神经病发生移植物抗宿主病的四例患者接受骨髓移植和伴随实体器官排斥反应（心脏和肾脏）的两名患者。神经病变累及近端和远端肌肉，表现为反射减退或反射消失，通常CSF蛋白升高。电生理学研究不符合脱髓鞘的严格标准。免疫抑制治疗后或移植物抗宿主病或组织排斥反应消退的同时，神经病变体征改善。多发性神经病必须被认为是组织移植的潜在并发症。
We report a generalized polyneuropathy coincident with the occurrence of graft-versus-host disease in four patients undergoing bone marrow transplantation and accompanying solid organ rejection (heart and kidney) in two patients. The neuropathy affected proximal and distal muscles, demonstrated hyporeflexia or areflexia, and usually had elevated CSF protein. Electrophysiologic studies did not meet strict criteria for demyelination. The signs of neuropathy improved after immunosuppressive treatment or simultaneous to the resolution of graft-versus-host disease or tissue rejection. Polyneuropathy must be considered as a potential complication of tissue transplantation.