Cytoskeletal waves in the absence of molecular motors
Cytoskeletal waves in the absence of molecular motors
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DOI：
10.1209/0295-5075/83/18003
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发表时间：
2008-01-01
期刊：
影响因子：
1.8
通讯作者：
Kruse, K.
中科院分区：
文献类型：
--
作者：
Doubrovinski, K.;Kruse, K.
波是在基底上爬行或扩散的细胞的细胞骨架中普遍存在的现象。在理论分析中，细胞骨架波被归因于分子马达的作用，分子马达主动交联细胞骨架。哀叹。最近的观察人类中性粒细胞的细胞骨架波的动机，我们开发了一个描述的milling。在成核蛋白的存在下，当结合到与基底相邻的膜上时，成核蛋白是活性的。如果这些蛋白质合作地结合到膜上，即使在没有分子马达的情况下，我们也会发现行波。在一个有限的领域，系统可以组织成一对反向旋转的螺旋发射平面波。版权所有（C）EPLA，2008.
Waves are a ubiquitous phenomenon in the cytoskeleton of cells crawling or spreading on a substrate. In theoretical analysis, cytoskeletal waves have been attributed to the action of molecular motors that actively cross-link cytoskeletal. laments. Motivated by recent observations of cytoskeletal waves in human neutrophils, we develop a description of treadmilling. laments in the presence of nucleating proteins that are active when bound to the membrane adjacent to the substrate. If these proteins bind cooperatively to the membrane, we find traveling waves even in the absence of molecular motors. In a confined domain the system can organize into a pair of counter-rotating spirals that emit planar waves. Copyright (C) EPLA, 2008.