Reflex mechanisms in gastroesophageal reflux disease and asthma
Reflex mechanisms in gastroesophageal reflux disease and asthma
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DOI：
10.1016/s0002-9343(03)00192-x
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发表时间：
2003-08-18
影响因子：
5.9
通讯作者：
Mazzone, SB
中科院分区：
文献类型：
--
作者：
Canning, BJ;Mazzone, SB
本文简要介绍了引起咳嗽和支气管痉挛的反射机制，并确定了胃食管反流（格尔）可能引起这些反射的几种潜在机制。与各种机械感受器和化学感受器相关的气道和食管反射已被阐明，主要是在动物研究中。中枢神经系统（CNS）反射通路以及局部轴突反射均可能参与哮喘和格尔病（GERD）的发病机制。当被激活时，气道伤害感受器会引起防御性反射，如咳嗽、支气管痉挛和粘液分泌。支配气道和食管的伤害感受器对类似的刺激做出防御性反应。一些食管和气道感觉神经的通路终止于CNS的相同区域。食管伤害感受器和气道感觉神经之间的协同相互作用可能促成与GERD相关的哮喘样症状。(C)2003年，Excerpta Medica，Inc.
This article presents a brief description of the reflex mechanisms responsible for cough and bronchospasm, and identifies several potential mechanisms by which gastroesophageal reflux (GER) may precipitate these reflexes. Airway and esophageal reflexes related to various mechanoreceptors and chemoreceptors have been elucidated, primarily in animal studies. Central nervous system (CNS) reflex pathways as well as local axon reflexes may each contribute to the pathogenesis of both asthma and GER disease (GERD). When activated, airway nociceptors precipitate defensive reflexes such as cough, bronchospasm, and mucus secretion. Nociceptors innervating both the airways and the esophagus respond to similar stimuli with defensive manuevers. The pathways of some esophageal and airway sensory nerves terminate in the same regions of the CNS. It appears possible that synergistic interactions between esophageal nociceptors and airway sensory nerves may precipitate the asthma-like symptoms associated with GERD. (C) 2003 by Excerpta Medica, Inc.