Biomimetic Synthesis of Complex Flavonoids Isolated from Daemonorops "Dragon's Blood".
Biomimetic Synthesis of Complex Flavonoids Isolated from Daemonorops "Dragon's Blood".
复制标题
DOI：
10.1002/anie.201705390
复制
发表时间：
2017-09
影响因子：
--
通讯作者：
M. Schmid;D. Trauner
中科院分区：
文献类型：
--
作者：
M. Schmid;D. Trauner
龙血素是一对复杂的类黄酮三聚体，已从棕榈树Daemonorops draco中分离出来，这是被称为“龙血”的古老树脂的来源之一。我们提出了一个简短的合成，澄清了它们的相对配置，并揭示了它们在自然界中的起源。这种合成的特点是涉及离子和自由基中间体的仿生级联反应。讨论了血竭素、血竭素C与龙血素A1、A2的亲缘关系。
The dragonbloodins are a pair of complex flavonoid trimers that have been isolated from the palm tree Daemonorops draco, one of the sources of the ancient resin known as "dragon's blood". We present a short synthesis that clarifies their relative configurations and sheds light on their origin in Nature. This synthesis features biomimetic cascade reactions that involve both ionic and radical intermediates. The biogenetic relationships between dracorhodin, the dracoflavans C, and the dragonbloodins A1 and A2 are discussed.