Nitric oxide in migraine.
Nitric oxide in migraine.
复制标题
DOI：
10.2174/187152707781387233
复制
发表时间：
2007-07
期刊：
影响因子：
--
通讯作者：
L. Neeb;U. Reuter
中科院分区：
文献类型：
--
作者：
L. Neeb;U. Reuter
强有力的血管扩张剂和信使分子一氧化氮（NO）被认为在偏头痛发病机制中起关键作用。三硝酸甘油（GTN）等供体不会引起头痛。GTN的输注导致偏头痛患者的偏头痛发作，潜伏期为4至6小时。在这篇综述中，我们集中在一氧化氮和转录因子核因子-κ B（NF-κ B）在人类和动物模型偏头痛的病理生理学的作用。NO主要以环磷酸鸟苷（cGMP）依赖的方式参与疼痛传递、痛敏、慢性疼痛、炎症和中枢敏化。我们的目的是说明如何NO是牵连在偏头痛患者的偏头痛发作的诱导和如何实验动物模型可能有助于阐明人类GTN反应的机制。由于NO在偏头痛中的作用，我们试图评估预防性偏头痛药物的作用是否以及如何涉及NO途径。更多关于NO参与偏头痛发病的知识也可能为急性偏头痛治疗提供未来可能的治疗靶点。
The potent vasodilatator and messenger molecule nitric oxide (NO) is believed to play a key role in migraine pathogenesis. NO donors such as glyceryl trinitrate (GTN) can cause headache. Infusion of GTN leads to a migraine attack in migraineurs with a latency of 4 to 6 hours. In this review we focus in the role of nitric oxide and the transcription factor nuclear factor-kappaB (NF-kappaB) in migraine pathophysiology in humans and animal models. NO is involved in pain transmission, hyperalgesia, chronic pain, inflammation and central sensitization mostly in a cyclic guanosinemono-phosphate (cGMP) dependent way. We aim to illustrate how NO is implicated in the induction of a migraine attack in migraineurs and how experimental animal models may help to elucidate the mechanisms of the human GTN response. Because of the role of NO in migraine we try to assess if and how the action of preventative migraine drugs involves the NO pathways. More knowledge about the involvement of NO in the genesis of migraine headache may also provide possible future therapeutic targets for acute migraine therapy.