Plasma and drainage fluid levels of soluble receptor activator of nuclear factor-kB (sRANK), soluble receptor activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) during proximal humerus fracture healing
Plasma and drainage fluid levels of soluble receptor activator of nuclear factor-kB (sRANK), soluble receptor activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) during proximal humerus fracture healing
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DOI：
10.1007/s00264-010-1088-3
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发表时间：
2011-05
影响因子：
2.7
通讯作者：
A. Colombini;G. Lombardi;E. Galliera;G. Dogliotti;P. Randelli;Alexander Meerssemann;Giuseppe Mineo;P. Cabitza;M. Corsi
中科院分区：
文献类型：
--
作者：
A. Colombini;G. Lombardi;E. Galliera;G. Dogliotti;P. Randelli;Alexander Meerssemann;Giuseppe Mineo;P. Cabitza;M. Corsi
骨折愈合是恢复骨结构完整性的有序过程。可溶性核因子κ B受体激活因子（sRANK）及其配体（sRANKL）和骨保护素（OPG）参与骨重建，可能在骨折修复中发挥作用。在10名需要接骨术的肱骨近端骨折患者（年龄范围26-65岁）中，从术前至愈合期间采集血浆和引流液中的OPG、可溶性RANK和RANKL水平。所有患者骨折均愈合。未观察到sRANKL和OPG浓度的显著变化，而与术中时间相比，术后24小时sRANK显示引流液显著增加。在每个时间点，血浆和引流液中的OPG水平均高于sRANK和sRANKL。由于没有关于sRANK参与骨折愈合的已发表数据，我们的研究代表了术后立即局部增加该标志物浓度的第一个初步迹象。
Fracture healing is an ordered process that restores the structural integrity of the bone. Soluble receptor activator of nuclear factor-kB (sRANK), its ligand (sRANKL) and osteoprotegerin (OPG) are involved in bone remodelling, thus they may play a role in fracture repair. OPG, soluble RANK and RANKL levels were measured in plasma and in drainage fluid, collected from pre-surgery phase to healing in ten patients of both genders (age range 26–65 years) with proximal humerus fracture needing osteosynthesis. All patients showed fracture healing. No significant modifications in the concentrations of sRANKL and OPG were observed, while sRANK showed a significant increase in drainage fluid 24 hours post-surgery compared with intra-surgery time. OPG levels were higher in plasma and drainage fluid than sRANK and sRANKL at each time point. Since there are no published data about sRANK involvement in fracture healing, our study represents the first preliminary indication about a local increase of this marker concentration immediately after surgery.