Early life sleep disruption has long lasting, sex specific effects on later development of sleep in prairie voles.
Early life sleep disruption has long lasting, sex specific effects on later development of sleep in prairie voles.
复制标题
早期的睡眠破坏对草原田鼠的晚期睡眠发展具有持久的特定性影响。
DOI：
10.1016/j.nbscr.2022.100087
复制
发表时间：
2023-05
影响因子：
--
通讯作者：
Lim, Miranda M
中科院分区：
文献类型：
--
作者：
Jones-Tinsley, Carolyn E;Olson, Randall J;Mader, Miranda;Wickham, Peyton T;Gutowsky, Katelyn;Wong, Claire;Chu, Sung Sik;Milman, Noah E P;Cao, Hung;Lim, Miranda M
对于哺乳动物来说，睡眠持续时间在产后早期最长，对于塑造控制复杂行为发展的神经回路至关重要。草原田鼠是一种野生的、高度社会化的啮齿动物，是研究复杂的、物种典型的社会行为的独特模型。我们实验室之前的工作发现，草原田鼠在出生后发育敏感窗口期间的早期睡眠中断（ELSD）会导致社交和认知行为的长期持续变化，以及大脑兴奋性和抑制性神经回路的结构变化。然而，目前尚不清楚 ELSD 对后期睡眠有何影响，无论是在 ELSD 之后不久还是长期来看。因此，本研究的目的是描述与正常发育的草原田鼠的睡眠相比，ELSD 对晚年睡眠的影响。首先，我们对接受 ELSD 的幼年草原田鼠进行了系留脑电图/肌电图 (EEG/EMG) 记录，并与对照条件进行了比较。其次，我们对青少年或成年雄性和雌性草原田鼠进行了 24 小时的家笼拴系脑电图/肌电图记录，这些草原田鼠在幼年时曾接受过 ELSD 或对照条件。我们发现，与对照组相比，成年后，雄性 ELSD 草原田鼠的 REM 睡眠持续时间持续较短，而雌性 ELSD 草原田鼠的 NREM 睡眠持续时间持续较高，但其他睡眠参数没有差异。我们得出的结论是：1）ELSD 对成年期睡眠的持续影响可能会导致成年田鼠出现社交和认知缺陷，2）生命早期的睡眠中断可能会影响成年后的睡眠模式。生命早期睡眠中断（ELSD）持续减少幼年草原田鼠的快速眼动（REM）睡眠时间。与年龄和性别匹配的对照组相比，在产后第三周接受 ELSD 的成年男性的快速眼动睡眠时间减少。 ELSD 对雌性草原田鼠的快速眼动睡眠没有持续影响。
In mammals, sleep duration is highest in the early postnatal period of life and is critical for shaping neural circuits that control the development of complex behaviors. The prairie vole is a wild, highly social rodent that serves as a unique model for the study of complex, species-typical social behaviors. Previous work in our laboratory has found that early life sleep disruption (ELSD) in prairie voles during a sensitive window of postnatal development leads to long lasting changes in social and cognitive behaviors as well as structural changes in excitatory and inhibitory neural circuits in the brain. However, it is currently unknown how later sleep is impacted by ELSD, both shortly after ELSD and over the long term. Therefore, the aim of this study was to describe the effects of ELSD on later life sleep, compared to sleep in normally developing prairie voles. First, we conducted tethered electroencephalogram/electromyogram (EEG/EMG) recordings in juvenile prairie voles undergoing ELSD, compared to Control conditions. Second, we conducted 24 h of home cage tethered EEG/EMG recordings in either adolescent or adult male and female prairie voles that had previously undergone ELSD or Control conditions as juveniles. We found that, as adults, male ELSD prairie voles showed persistently lower REM sleep duration and female ELSD prairie voles showed persistently higher NREM sleep duration compared to Controls, but no other sleep parameters differed. We concluded that 1) persistent effects of ELSD on sleep into adulthood may contribute to the social and cognitive deficits observed in adult voles, and 2) sleep disruption early in life can influence later sleep patterns in adulthood. Early life sleep disruption (ELSD) persistently reduces Rapid Eye Movement (REM) sleep time in juvenile prairie voles. Adult males subjected to ELSD in their 3rd postnatal week had reduced REM sleep compared to age and sex matched Controls. There were no persistent effects of ELSD on REM sleep in female prairie voles.