Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice
Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice
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DOI：
10.5551/jat.e486
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发表时间：
2007-10-01
影响因子：
4.4
通讯作者：
Masuno, Hiroshi
中科院分区：
文献类型：
--
作者：
Miyawaki, Joji;Sakayama, Kenshi;Masuno, Hiroshi
目的：探讨围产期和产后暴露于双酚A（BPA）的小鼠是否会导致肥胖和/或高脂血症的发展。方法：妊娠小鼠从妊娠第10天开始，在整个哺乳期暴露于饮用水中的BPA浓度为1 μ g/mL（LD组）或10 μ g/mL（HD组）。断奶后，允许幼鼠自由饮用含有适当浓度BPA的饮用水。结果：LD组和HD组雌性仔鼠平均体重分别比对照组增加13%（P <0.05）和11%（p <0.05），LD组仔鼠平均体重比对照组增加11%（p< 0.05），HD组仔鼠平均体重比对照组增加10%（p< 0.05），HD组仔鼠平均体重比对照组增加10%（p <0.05）。
Aim: To investigate whether the perinatal and postnatal exposure of mice to bisphenol A (BPA) caused the development of obesity and/or hyperlipidemia.Methods: Pregnant mice were exposed to BPA in drinking water at concentrations of either 1 mu g/mL (LD group) or 10 mu g/mL (HD group) from gestation day 10 and throughout the lactating period. After weaning, the pups were allowed free access to drinking water containing the appropriate concentrations of BPA. The body weight, adipose tissue weight, and serum lipid levels were measured in the offspring at postnatal day 31.Results: In females, the mean body weight increased by 13% in the LD group (p< 0.05) and 11% in the HD group (P