Oral colonization of Candida species in patients receiving radiotherapy in the head and neck area.
Oral colonization of Candida species in patients receiving radiotherapy in the head and neck area.
复制标题
在头颈部接受放射治疗的患者体内念珠菌的口腔定植。
DOI：
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发表时间：
2008
影响因子：
1.9
通讯作者：
S. Choonharuangdej
中科院分区：
文献类型：
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作者：
S. Thaweboon;B. Thaweboon;T. Srithavaj;S. Choonharuangdej
目的
通过常规程序（包括在显色培养基上培养印迹样品和随后使用分析特征指数检测进行鉴定），研究接受头颈癌放射治疗的患者与对照组的口腔念珠菌菌株多样性。
方法和材料
从玛希隆大学颌面修复服务中心招募了22名年龄在18至55岁之间的辐照患者。同时，选择22名年龄和性别与患者组相匹配的健康个体作为对照组。
结果
所有患者均为念珠菌携带者，以白色念珠菌感染为主（86.36%）。除白色念珠菌外，这些患者口腔中的其他酵母菌为光滑念珠菌、克柔念珠菌和热带念珠菌。对照组念珠菌携带率相对较低（45.45%）。然而，白色念珠菌仍然是检测到的主要菌种。两组均未发现都柏林念珠菌。
结论
接受放射治疗的头颈部癌症患者口腔念珠菌定植的患病率较高。因此，需要预防以减少这些患者的念珠菌感染。这可能会改善接受放射治疗的恶性癌症患者的生活质量。
OBJECTIVE
To investigate oral Candida strain diversity in patients receiving radiation therapy for head and neck cancer compared to controls by conventional procedures, including cultivation of imprint samples on chromogenic medium and subsequent identification using Analytical Profile Index testing.
METHOD AND MATERIALS
Twenty-two irradiated patients aged 18 to 55 years were recruited from the Maxillofacial Prosthetic Service, Mahidol University. Concomitantly, 22 healthy individuals whose age and sex matched that of the patient group were selected for a control group.
RESULTS
All patients studied were Candida carriers and were predominantly infected with Candida albicans (86.36%). Besides C albicans, other yeasts colonizing the oral cavity of these patients were C glabrata, C krusei, and C tropicalis. Candida carriage was found relatively less frequently (45.45%) in control subjects. However, C albicans was still the predominant species detected. No C dubliniensis was found in either group.
CONCLUSION
Head and neck cancer patients who had received radiotherapy had a high prevalence of Candida colonization in the oral cavity. Consequently, prophylaxis to reduce Candida infection in these patients is required. This may improve the quality of life for patients who receive irradiation treatment for malignant cancer.