Determination of Two Binary Vitamin Mixtures Using Difference and Derivative Spectrophotometry
Determination of Two Binary Vitamin Mixtures Using Difference and Derivative Spectrophotometry
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使用差值和导数分光光度法测定两种二元维生素混合物
DOI：
10.1080/00032719308017464
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发表时间：
1993
影响因子：
2
通讯作者：
I. Hewala
中科院分区：
文献类型：
--
作者：
I. Hewala
摘要 描述了用于分析维生素二元混合物的简单、灵敏、快速和准确的分光光度测定程序。第一种混合物：盐酸吡哆醇 (PYRD) 和盐酸硫胺素 (THIA)：使用一阶导数和三阶导数分光光度法的组合进行分析，分别测定 PYRD 和 THIA。该方法适用于混浊混合物的分析，并用于研究片剂的溶出度。第二混合物；甲萘醌磷酸二钠（MENA）和抗坏血酸（ASCO）；使用二阶导数和差分光光度法进行分析，分别测定 MENA 和 ASCO。讨论了所提出方法的验证，并介绍了它们在片剂和安瓿分析中的应用。
Abstract Simple, sensitive, rapid and accurate spectrophotometric procedures are described for the analysis of binary mixtures of vitamins. The first mixture: pyridoxine hydrochloride (PYRD) and thiamine hydrochloride (THIA): is analyzed using a combination of first- and third- derivative spectrophotometry for the determination of PYRD and THIA, respectively. The method is applied for the analysis of turbid mixtures and adopted for studying the dissolution of tablets. The second mixture; menadione sodium biphosphate (MENA) and ascorbic acid (ASCO); is analyzed using a second derivative and difference spectrophotometric methods for determination of MENA and ASCO, respectively. The validation of the proposed methods is discussed and their application for the analysis of tablets and ampoules are presented.