Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-reducing, fear-reducing, and pain-reducing effects in ovariectomized rats
Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-reducing, fear-reducing, and pain-reducing effects in ovariectomized rats
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DOI：
10.1037/0735-7044.118.2.306
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发表时间：
2004-04-01
影响因子：
1.9
通讯作者：
Walf, AA
中科院分区：
文献类型：
--
作者：
Frye, CA;Walf, AA
杏仁核中的雌激素（E-2）和/或黄体酮(P)可能影响焦虑、恐惧和疼痛行为。分别给予去卵巢大鼠皮下或杏仁核内载药、E-2、P或E-2 + P，观察其对开阔场地、高架迷宫、防御性冷冻和热板任务表现的影响。与载药组相比，皮下e + P或杏仁核内E2、P或E2 + P增加了开放野区中央入口和开放臂时间。与载药相比，皮下或杏仁核内E-2、P或E2 + P减少了休克后的冷冻时间。与对照体相比，皮下或杏仁核内E2 + P的舔爪潜伏期增加。因此，E2和P可能对杏仁核有减少焦虑、恐惧和/或疼痛反应的作用。
Estrogen (E-2) and/or progesterone (P) in the amygdala may influence anxiety, fear, and pain behaviors. Ovariectomized rats were administered subcutaneous or intra-amygdala vehicle, E-2, P, or E-2 + P: Effects on open field, elevated plus-maze, defensive freezing, and hot-plate task performance were observed. Subcutaneous E. + P or intra-amygdala E2, P, or E2 + P increased open field central entries and open arm time in the plus-maze compared with vehicle. Subcutaneous or intra-amygdala E-2, P, or E2 + P decreased time spent freezing postshock compared with vehicle. Subcutaneous or intra-amygdala E2 + P increased latencies to lick paws compared with vehicle. Thus, E2 and P may have effects in the amygdala to decrease anxiety, fear, and/or pain responses.