Functional Imaging and Modeling of the Heart
Functional Imaging and Modeling of the Heart
复制标题
心脏的功能成像和建模
DOI：
10.1007/978-3-319-20309-6_48
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Kharche S
中科院分区：
文献类型：
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作者：
Kharche S
这项研究评估了人体心房解剖和纤维方向对低电压共振除颤方法有效性的影响。对Courtemmane-Ramirez-Nattel模型进行了修改，以模拟可能代表一种房颤形式的涡旋波再入。细胞模型被整合到一个3D解剖模型中，以模拟重返大气层。在各向同性和各向异性三维模型中，估计了消除再入的单次冲击阈值，作为低能除颤效果的参考点。低电压涡旋波终止协议是基于反馈控制的周期性刺激引起的静止涡旋波的共振漂移。全局共振反馈刺激原则上可以在真实感解剖模型中工作。为了在解剖模型中找到共振低能量除颤的最佳参数，进一步的研究必须包括电极的最佳位置以及刺激方案的改进。
This study evaluated the effects of human atrial anatomy and fibre orientation on the effectiveness of a low voltage resonant defibrillation method. The Courtemanche-Ramirez-Nattel model was modified to simulate scroll wave re-entry that may represent a form of atrial fibrillation. The cell models were incorporated into a 3D anatomical model to simulate re-entry. The single shock threshold to eliminate re-entry in the isotropic and anisotropic 3D models was estimated as the reference point for the low energy defibrillation effectiveness. The low voltage scroll wave termination protocol was based on the resonant drift of stationary scroll waves due to feedback-controlled periodic stimulation. The global resonant feedback stimulation can work in the realistic anatomy model in principle. Further investigation to find optimal parameters for the resonant low energy defibrillation in anatomically realistic models must include optimal location of electrodes as well as stimulation protocol improvement.