The utility of protein and mRNA correlation.
The utility of protein and mRNA correlation.
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DOI：
10.1016/j.tibs.2014.10.010
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发表时间：
2015-01
影响因子：
13.8
通讯作者：
Payne SH
中科院分区：
文献类型：
--
作者：
Payne SH
转录组学、蛋白质组学和代谢组学测量正在彻底改变我们建模和预测细胞行为的方式，多组学比较的出版越来越有规律。有些人认为mRNA和蛋白质之间存在微不足道的可预测的相关性;然而，生物调节的明显复杂性表明了一种更微妙的关系。事实上，观察这种缺乏严格相关性的现象为新的研究课题提供了线索，并有可能带来变革性的生物学见解。
Transcriptomic, proteomic, and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however, the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.