Analysis of the heat shock response of Neisseria meningitidis with cDNA- and oligonucleotide-based DNA microarrays
Analysis of the heat shock response of Neisseria meningitidis with cDNA- and oligonucleotide-based DNA microarrays
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DOI：
10.1128/jb.184.9.2546-2551.2002
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发表时间：
2002-05-01
影响因子：
3.2
通讯作者：
Dietrich, G
中科院分区：
文献类型：
--
作者：
Guckenberger, M;Kurz, S;Dietrich, G
基于寡核苷酸和cDNA的微阵列包括脑膜炎奈瑟氏球菌基因的一个子集进行了评估脑膜炎球菌热休克反应的研究，发现是非常适合的N。脑膜炎采用寡核苷酸阵列涵盖整个基因组的N。脑膜炎，我们分析了全球范围内的脑膜炎球菌热休克反应，并确定了55个热休克失调的开放阅读框架（34个诱导和21个抑制）。
Oligonucleotide- and cDNA-based microarrays comprising a subset of Neisseria meningitidis genes were assessed for study of the meningococcal heat shock response and found to be highly suitable for transcriptional profiling of N. meningitidis. Employing oligonucleotide arrays encompassing the entire genome of N. meningitidis, we analyzed the meningococcal heat shock response on a global scale and identified 55 heat shock-deregulated open reading frames (34 induced and 21 repressed).