Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation.
Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation.
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DOI：
10.3389/fphys.2022.1066460
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发表时间：
2022
影响因子：
4
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中科院分区：
文献类型：
--
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淋巴系统对维持间质液和蛋白质稳态至关重要。它在收集血管泄漏的过量血浆和间质液、消化系统脂质吸收和运输以及免疫监测和反应中具有重要作用。淋巴管的发育始于胎儿时期，淋巴内皮祖细胞首先通过表达淋巴血管主调控因子PROX1 （prospero-related homeobox 1）分化为淋巴内皮细胞（LECs）。淋巴脉管系统形成一个由盲端和单向血管组成的分层网络。尽管在阐明淋巴血管系统形成的细胞和分子机制方面取得了很大进展，但对淋巴管异常和疾病的原因了解甚少，而且很复杂；具体来说，淋巴管发育中转录失调的机制基础仍不清楚。在这篇综述中，我们讨论了淋巴血管发育的分子和细胞机制的最新进展，包括LEC分化、淋巴管生成和瓣膜形成，以及淋巴血管中机械力的意义，重点是转录调控。我们还总结了目前对淋巴基因表达的表观遗传机制的认识。
The lymphatic system is crucial for the maintenance of interstitial fluid and protein homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked from blood vessels, lipid absorption and transportation in the digestive system, and immune surveillance and response. The development of lymphatic vessels begins during fetal life as lymphatic endothelial progenitor cells first differentiate into lymphatic endothelial cells (LECs) by expressing the master lymphatic vascular regulator, prospero-related homeobox 1 (PROX1). The lymphatic vasculature forms a hierarchical network that consists of blind-ended and unidirectional vessels. Although much progress has been made in the elucidation of the cellular and molecular mechanisms underlying the formation of the lymphatic vascular system, the causes of lymphatic vessel abnormalities and disease are poorly understood and complicated; specifically, the mechanistic basis for transcriptional dysregulation in lymphatic vessel development remains largely unclear. In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms of lymphatic vascular development, including LEC differentiation, lymphangiogenesis, and valve formation, and the significance of mechanical forces in lymphatic vessels, with a focus on transcriptional regulation. We also summarize the current knowledge on epigenetic mechanisms of lymphatic gene expression.
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影响因子：
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作者：
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通讯作者：
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