Wireless Electrochemotherapy by Selenium-Doped Piezoelectric Biomaterials to Enhance Cancer Cell Apoptosis
Wireless Electrochemotherapy by Selenium-Doped Piezoelectric Biomaterials to Enhance Cancer Cell Apoptosis
复制标题
掺硒压电生物材料的无线电化学疗法增强癌细胞凋亡
DOI：
10.1021/acsami.0c04666
复制
发表时间：
2020-08-05
影响因子：
9.5
通讯作者：
Ning, Chengyun
中科院分区：
文献类型：
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作者：
Li, Changhao;Li, Yangfan;Ning, Chengyun
手术部位周围的癌症残留物仍然是癌症复发治疗失败的重要原因。为了预防肿瘤复发，同时修复手术造成的缺损，迫切需要开发具有抗肿瘤能力和良好生物活性的可植入生物材料。本工作将抗癌有效元素硒（Se）掺杂到钛酸钾钠压电陶瓷中，成功制备了功能化植入体，实现了电疗和化疗的无线联合。在此，我们证明，硒掺杂的压电植入物可以通过增加细胞内活性氧水平引起线粒体损伤，然后触发caspase-3途径，以显着促进骨肉瘤细胞在体外的凋亡。同时，其良好的生物相容性也得到了验证。这些结果对于未来部署无线电刺激和化学刺激来调节缺陷组织周围的生物过程具有重要意义。
Cancer residues around the surgical site remain a significant cause of treatment failure with cancer recurrence. To prevent cancer recurrence and simultaneously repair surgery-caused defects, it is urgent to develop implantable biomaterials with anticancer ability and good biological activity. In this work, a functionalized implant is successfully fabricated by doping the effective anticancer element selenium (Se) into the potassium-sodium niobate piezoceramic, which realizes the wireless combination of electrotherapy and chemotherapy. Herein, we demonstrate that the Se-doped piezoelectric implant can cause mitochondrial damage by increasing intracellular reactive oxygen species levels and then trigger the caspase-3 pathway to significantly promote apoptosis of osteosarcoma cells in vitro. Meanwhile, its good biocompatibility has been verified. These results are of great importance for future deployment of wireless electro- and chemostimulation to modulate biological process around the defective tissue.