Association between markers of arterial stiffness and atrial fibrillation in the Circulatory Risk in Communities Study (CIRCS).
Association between markers of arterial stiffness and atrial fibrillation in the Circulatory Risk in Communities Study (CIRCS).
复制标题
DOI：
10.1016/j.atherosclerosis.2017.06.918
复制
发表时间：
2017-08-01
期刊：
影响因子：
5.3
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
--
作者：
Cui, Renzhe;Yamagishi, Kazumasa;Iso, Hiroyasu
背景和目标：关于亚洲人群中动脉僵硬度标志物与房颤患病率之间的相关性的证据有限。因此，我们研究了这些协会在日本population.METHODS：我们进行了一项横断面人口为基础的研究4264名男性和女性年龄在40-79岁。动脉僵硬度的标志物增强指数（AI）计算为中心脉压/肱动脉脉压的比率，其中AI和中心主动脉压通过自动眼压计测量：HEM-9000 AI装置（Omron Healthcare co.，日本京都）。结果：AI值越大，房颤和总心律失常的发生率越高。在调整已知的心血管危险因素后，这些相关性没有改变。对于房颤和总心律失常，AI最高与最低三分位数的多变量比值比（95%置信区间）分别为3.4（1.4-8.6，p =0.008）和1.8（1.2-2.7，p =0.004）。中心或肱动脉脉压水平与房颤或总心律失常的患病率无相关性。结论：AI值，但不是肱动脉或中心脉压，与房颤和总心律失常的患病率呈正相关，独立于心血管危险因素。
BACKGROUND AND AIMS: Limited evidence is available on the association between markers of arterial stiffness and the prevalence of atrial fibrillation among Asian populations. Therefore, we examined those associations in the Japanese population.METHODS: We conducted a cross-sectional population-based study of 4264 men and women aged 40-79 years. The augmentation index (AI), a marker of arterial stiffness, was calculated as the ratio of central pulse pressure/brachial pulse pressure, where the AI and central aortic pressure were measured by an automated tonometer: the HEM-9000AI device (Omron Healthcare co., Kyoto, Japan). Atrial fibrillation was estimated by the Minnesota codes using resting electrocardiograph (ECG).RESULTS: The prevalence of atrial fibrillation and total arrhythmia were higher with larger AI values. These associations did not change after adjustment for known cardiovascular risk factors. The multivariable odd ratios (95% confidence intervals) in the highest versus lowest tertiles of AI were 3.4 (1.4-8.6, p for trend=0.008) for atrial fibrillation and 1.8 (1.2-2.7, p for trend=0.004) for total arrhythmia. There was no association of central or brachial pulse pressure levels with the prevalence of atrial fibrillation or total arrhythmia.CONCLUSIONS: AI values, but not brachial or central pulse pressures, were positively associated with the prevalence of atrial fibrillation and total arrhythmia, independent of cardiovascular risk factors.