Variability in Pathobiology of South Korean H5N1 High-Pathogenicity Avian Influenza Virus Infection for 5 Species of Migratory Waterfowl
Variability in Pathobiology of South Korean H5N1 High-Pathogenicity Avian Influenza Virus Infection for 5 Species of Migratory Waterfowl
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DOI：
10.1177/0300985809359602
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发表时间：
2010-05-01
影响因子：
2.4
通讯作者：
Swayne, D. E.
中科院分区：
文献类型：
--
作者：
Kwon, Y. K.;Thomas, C.;Swayne, D. E.
H5 N1高致病性禽流感病毒感染野生水禽的病理生物学机制尚不清楚。本研究在5种迁徙水禽中检测了A/chicken/Korea/IS/06（H5 N1）HPAI的病理生物学，这些水禽包括：疣鼻天鹅（Cygnus olor）、灰雁（Anser anser）、赤麻鸭（Tadorna ferrugalus）、鸳鸯（Aix galericulata）和野鸭（Anas platyrhynchos）--通过鼻内接种或接触暴露，所有鸟类均被感染。在疣鼻天鹅中，该病毒具有强烈的血管内皮细胞嗜性，产生急性重症和100%死亡率;在各种实质细胞中检测到该病毒;在一系列器官中观察到坏死和炎症变化，包括胰腺、脑、脾、心脏、口腔、肾上腺、肺和肝脏。红麻鸭的死亡率为100%，但死亡时间延迟，病变主要限于脑、心脏、胰腺和脾脏。鸳鸯只有一次死亡，病变与红麻鸭相似。灰雁被感染，神经系统症状，并有残留的脑膜脑炎时，检查终止，但没有死亡率。野鸭无症状感染。这些结果表明，H5 N1病毒感染不同种类的野生水禽的病理生物学的变化，从严重的，急性全身性疾病的死亡率为100%，呼吸道和胃肠道系统的无症状感染。
The pathobiology of H5N1 high-pathogenicity avian influenza (HPAI) virus infection in wild waterfowl is poorly understood. This study examined the pathobiology of A/chicken/Korea/IS/06 (H5N1) HPAI in 5 migratory waterfowl species mute swans (Cygnus olor), greylag geese (Anser anser), ruddy shelducks (Tadorna ferruginea), mandarin ducks (Aix galericulata), and mallard ducks (Anas platyrhynchos)-following intranasal inoculation or contact exposure, from which all birds became infected. In mute swans, this virus had strong vascular endothelial cell tropism, producing acute severe disease and 100% mortality; the virus was detected in various parenchymal cells; and necrotic and inflammatory changes were noted in a range of organs, including pancreas, brain, spleen, heart, oral cavity, adrenal gland, lung, and liver. The ruddy shelducks had 100% mortality, but time to death was delayed, and the lesions were primarily restricted to the brain, heart, pancreas, and spleen. The mandarin ducks had only a single mortality, with lesions similar to those in ruddy shelducks. The greylag geese became infected, developed neurological signs, and had residual meningoencephalitis when examined at termination but lacked mortality. The mallards had asymptomatic infection. These results indicate variation in the pathobiology of H5N1 virus infections in different species of wild waterfowl, ranging from severe, acute systemic disease with 100% mortality to asymptomatic infection of respiratory and gastrointestinal systems.