Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion
Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion
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DOI：
10.1007/s00417-009-1271-7
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发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Avci, Remzi
中科院分区：
文献类型：
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作者：
Kaderli, Aysel Aydin;Kaderli, Berkant;Avci, Remzi
主动脉扩张性（AD）和脉搏波速度（PWV）反映动脉僵硬度，这与动脉粥样硬化、高血压和糖尿病等不同疾病的心血管发病率和死亡率增加有关，所有这些疾病也是分支视网膜静脉阻塞（BRVO）患者的常见风险因素。在本研究中，我们旨在确定BRVO患者动脉树不同节段的动脉硬度是否增加。研究组由35例BRVO患者组成（20名女性，15名男性，平均年龄：55.9 ± 6.8）和年龄匹配的对照组包括19名高血压患者（9名女性，10名男性，平均年龄：55.2 ± 7.6）和17名健康受试者（9名女性，8名男性，平均年龄：53.4 ± 9.6）。使用脉搏波传感器HDI系统测量桡动脉PWV，该系统通过舒张期衰减的计算机分析无创地测量桡动脉脉搏波记录，并提供大动脉弹性指数（LAEI）和小动脉弹性指数（SAEI）的单独评估。根据主动脉直径和压力随每次心脏搏动的变化之间的关系，通过超声心动图确定主动脉应变和AD。排除糖尿病或炎性BRVO患者和任何闭塞性血管性眼病的对照患者。结果显示，BRVO组LAEI值低于健康对照组（P < 0.05）。BRVO组的AD和主动脉应变均显著低于两个对照组（均为p < 0.05），高血压对照组显著低于健康对照组（p < 0.05）。AD、LAEI和SAEI呈正相关（分别为p = 0.021、r = 0.307和p = 0.041、r = 0.269）。动脉僵硬度可能在BRVO的发生或进展中起作用。AS在BRVO发病机制中的确切作用，以及AS在预测BRVO患者全身发病率和死亡率方面的价值，还需要进一步研究。
Aortic distensibility (AD) and pulse wave velocity (PWV) reflect arterial stiffness, which is linked to increased cardiovascular morbidity and mortality in different diseases such as atherosclerosis, hypertension, and diabetes mellitus, all of which are also common risk factors in patients with branch retinal vein occlusion (BRVO). In the present study, we aimed to determine whether arterial stiffness in different segments of the arterial tree is increased in patients with BRVO.The study group consisted of 35 patients with BRVO (20 female, 15 male, mean age: 55.9 +/- 6.8) and the age-matched control groups consisted of 19 patients with hypertension (9 female, 10 male, mean age: 55.2 +/- 7.6) and 17 healthy subjects (9 female, 8 male, mean age: 53.4 +/- 9.6). Radial artery PWV was measured using a Pulse Wave Sensor HDI system, which measures non-invasively the radial pulse-wave recording with computer analysis of the diastolic decay, and provides separate assessment of the large arterial elasticity index (LAEI) and small artery elasticity index (SAEI). Aortic strain and AD was determined echocardiographically based on the relationship between changes in aortic diameter and pressure with each cardiac pulse. Patients with diabetes mellitus or inflammatory BRVO, and control patients with any occlusive vascular eye disease, were excluded. The results of the three groups were compared.Compared to the subjects of the healthy control group, those with BRVO had lower LAEI (p < 0.05). Both AD and aortic strain were significantly lower in the BRVO group than in both control groups (p < 0.05 for both) and in the hypertensive control group than the healthy controls (p < 0.05). The AD, LAEI and SAEI were positively correlated (p = 0.021, r = 0.307 and p = 0.041, r = 0.269 respectively).The results of this study show that the arterial stiffness indices (large arterial elasticity index and aortic distensibility) are abnormal in patients with BRVO compared to the healthy and hypertensive controls. Arterial stiffness may play a role in the onset or progression of BRVO. Further studies are needed to determine the exact role of AS in the pathogenesis of BRVO, and to reveal its value in predicting systemic morbidity and mortality in patients with BRVO.