Expression of tropomyosin isoforms in benign and malignant human breast lesions
Expression of tropomyosin isoforms in benign and malignant human breast lesions
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DOI：
10.1038/bjc.1996.162
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发表时间：
1996-04-01
影响因子：
8.8
通讯作者：
Auer, G
中科院分区：
文献类型：
--
作者：
Franzen, B;Linder, S;Auer, G
高分子量原肌球蛋白（tms）通常在癌基因转化的成纤维细胞中下调。以前的研究也表明，特定的tm异构体在人乳腺癌细胞系中下调。我们研究了从非癌性乳腺病变和原发性乳腺癌制备的细胞中的原肌球蛋白亚型。癌中所有三种高分子量tm同种型（tm 1-3）的平均表达水平通常低于非癌性乳腺病变中观察到的平均表达水平的25%。有趣的是，与没有转移证据的原发性肿瘤相比，发现转移到腋窝淋巴结的原发性肿瘤中tm 1的表达高1.7倍（P
High molecular weight tropomyosins (tms) are commonly down-regulated in fibroblasts transformed by oncogenes. Previous studies have also demonstrated that specific tm isoforms are downregulated in human breast carcinoma cell lines. We examined tropomyosin isoforms in cells prepared from noncancerous breast lesions and primary human breast carcinomas. The average level of expression of all three high molecular weight tm isoforms (tm 1-3) in carcinomas was generally found to be less than 25% of that observed in non-cancerous breast lesions. Interestingly, the expression of tm 1 was found to be 1.7-fold higher in primary tumours with metastatic spread to axillary lymph nodes compared with primary tumours with no evidence of metastasis (P