Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism
Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism
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DOI：
10.1093/scan/nst156
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发表时间：
2014-10-01
影响因子：
4.2
通讯作者：
Wenderoth, Nicole
中科院分区：
文献类型：
--
作者：
Alaerts, Kaat;Woolley, Daniel G.;Wenderoth, Nicole
神经发育中断被认为是导致自闭症谱系障碍（ASD）行为改变的原因。在这里，我们结合测量的内在功能连接（iFC）从静息态功能磁共振成像（fMRI）与基于任务的fMRI，以探讨是否改变活动和/或iFC的右后上级颞沟（pSTS）介导的缺陷，在ASD的情绪识别。15名患有ASD的成年人和15名匹配的对照组进行了静息状态和基于任务的fMRI，在此期间，参与者将情绪状态与点光显示（PLD）区分开来。使用自闭症脑成像数据交换（ABIDE）的584（278 ASD/306对照）静息状态数据进一步检查右侧pSTS的固有FC。ASD参与者在识别PLD的情绪状态方面不如对照组准确。分析显示，明显的ASD相关的减少任务为基础的活动和休息状态iFC的权利pSTS与额顶叶地区通常包括行动观察网络（AON）。值得注意的是，pSTS-低活性与pSTS-低连接性相关，并且这两种测量都可以预测情绪识别性能，每种测量都解释了方差的独特部分。使用大型独立ABIDE数据集进行的分析复制了额顶叶区pSTS-iFC的减少。这些研究结果提供了新的证据，pSTS低活性和与额顶AON的低连接与ASD的社会缺陷特征有关。
Neurodevelopmental disconnections have been assumed to cause behavioral alterations in autism spectrum disorders (ASDs). Here, we combined measurements of intrinsic functional connectivity (iFC) from resting-state functional magnetic resonance imaging (fMRI) with task-based fMRI to explore whether altered activity and/or iFC of the right posterior superior temporal sulcus (pSTS) mediates deficits in emotion recognition in ASD. Fifteen adults with ASD and 15 matched-controls underwent resting-state and task-based fMRI, during which participants discriminated emotional states from point light displays (PLDs). Intrinsic FC of the right pSTS was further examined using 584 (278 ASD/306 controls) resting-state data of the Autism Brain Imaging Data Exchange (ABIDE). Participants with ASD were less accurate than controls in recognizing emotional states from PLDs. Analyses revealed pronounced ASD-related reductions both in task-based activity and resting-state iFC of the right pSTS with fronto-parietal areas typically encompassing the action observation network (AON). Notably, pSTS-hypo-activity was related to pSTS-hypo-connectivity, and both measures were predictive of emotion recognition performance with each measure explaining a unique part of the variance. Analyses with the large independent ABIDE dataset replicated reductions in pSTS-iFC to fronto-parietal regions. These findings provide novel evidence that pSTS hypo-activity and hypo-connectivity with the fronto-parietal AON are linked to the social deficits characteristic of ASD.