Diagnosis for COVID-19: current status and future prospects
Diagnosis for COVID-19: current status and future prospects
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DOI：
10.1080/14737159.2021.1894930
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发表时间：
2021-02
影响因子：
5.1
通讯作者：
Alamgir Kabir;R. Ahmed;S. M. A. Iqbal;R. Chowdhury;R. Paulmurugan;U. Demirci;W. Asghar
中科院分区：
文献类型：
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作者：
Alamgir Kabir;R. Ahmed;S. M. A. Iqbal;R. Chowdhury;R. Paulmurugan;U. Demirci;W. Asghar
摘要简介：新冠肺炎是由新型严重急性呼吸综合征冠状病毒2型引起的呼吸系统疾病，于2019年12月在武汉首次发现(中国)，并在全球范围内传播。2020年3月，世界卫生组织宣布新冠肺炎为大流行疾病。利用及时、准确的SARS-CoV-2病毒分子诊断，隔离和治疗感染者是控制这一史无前例的大流行的关键。国际旅行是病毒广泛传播的催化剂。涉及的领域：这篇综述讨论了识别元件和引物的表型、结构和分子进化，它在实验室中的检测，以及在护理点。此外，还对商业产品的市场分析及其性能进行了评估，为应对正在进行的全球公共卫生紧急情况提供了新的方法。专家评论：新冠肺炎的爆发在医疗行业造成了巨大的混乱，但每天仍有新的疫情中心被报道。应把重点放在开发更有效、更快速和更早的诊断设备上。检测实验室应该在临床相关、多路复用和可扩展的检测工具上投入更多资金，以对抗像这样存在大量检测需求的大流行。
ABSTRACT Introduction: Coronavirus disease 2019 (COVID-19), a respiratory illness caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had its first detection in December 2019 in Wuhan (China) and spread across the world. In March 2020, the World Health Organization (WHO) declared COVID-19 a pandemic disease. The utilization of prompt and accurate molecular diagnosis of SARS-CoV-2 virus, isolating the infected patients, and treating them are the keys to managing this unprecedented pandemic. International travel acted as a catalyst for the widespread transmission of the virus. Areas covered: This review discusses phenotype, structural, and molecular evolution of recognition elements and primers, its detection in the laboratory, and at point of care. Further, market analysis of commercial products and their performance are also evaluated, providing new ways to confront the ongoing global public health emergency. Expert commentary: The outbreak for COVID-19 created mammoth chaos in the healthcare sector, and still, day by day, new epicenters for the outbreak are being reported. Emphasis should be placed on developing more effective, rapid, and early diagnostic devices. The testing laboratories should invest more in clinically relevant multiplexed and scalable detection tools to fight against a pandemic like this where massive demand for testing exists.