miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6
miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6
复制标题
miR-137通过靶向Cdc42和Cdk6抑制肺癌细胞增殖
DOI：
10.1016/j.febslet.2012.11.004
复制
发表时间：
2013-01-04
期刊：
影响因子：
3.5
通讯作者：
Xu, Wenlin
中科院分区：
文献类型：
--
作者：
Zhu, Xiaolan;Li, Yuefeng;Xu, Wenlin
MicroRNA（miRNA）已成为致癌作用的关键参与者。在此，我们研究了miR-137在肺癌发病机制中的作用。肺癌细胞中miR-137的下调可以通过抑制DNA甲基化来挽救。miR-137在肺癌细胞中的异位表达显著下调Cdc 42、Cdk 6，并诱导G1期细胞阻滞，导致体内外细胞生长显著下降。此外，Cdc 42和Cdk 6均被证实为miR-137的靶点。皇冠版权所有（C）2012由Elsevier B出版。V.代表欧洲生物化学学会联合会。All rights reserved.
MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 in the pathogenesis of lung cancer. The downregulation of miR-137 in lung cancer cells could be rescued following inhibition of DNA methylation. Ectopic expression of miR-137 in lung cancer cells significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease in cell growth in vivo and in vitro. Further, both Cdc42 and Cdk6 were confirmed as targets of miR-137. Crown Copyright (C) 2012 Published by Elsevier B. V. on behalf of Federation of European Biochemical society. All rights reserved.