The ER function BiP is a master regulator of ER function.
The ER function BiP is a master regulator of ER function.
复制标题
DOI：
--
复制
发表时间：
2004-10
期刊：
影响因子：
--
通讯作者：
L. Hendershot
中科院分区：
文献类型：
--
作者：
L. Hendershot
内质网（ER）是细胞的指挥中心，就其对其他细胞器和活动的影响范围而言，仅次于细胞核。它是蛋白质合成的主要位点，含有作为许多信号传导途径的必要组分的细胞钙储存，并且是响应细胞应激条件并用于维持细胞稳态的信号转导级联的近端位点。所有真核细胞都具有ER，其可以包含细胞膜的近50%。它的功能可以分为发生在膜的胞质侧（蛋白质翻译和信号转导级联发生的地方）和腔空间（大多数其他ER功能发生的地方）。在过去的几年中，我们的研究表明，ER分子伴侣BiP是ER功能的主要调节剂。它负责在蛋白质易位期间维持ER的渗透性屏障，指导蛋白质折叠和组装，靶向错误折叠的蛋白质进行逆行易位，使它们可以被蛋白酶体降解，有助于ER钙储存，并在该细胞器中感知应激条件，以激活哺乳动物未折叠蛋白质反应。
The endoplasmic reticulum (ER) is a command center of the cell that is second only to the nucleus in terms of the breadth of its influence on other organelles and activities. It is a major site of protein synthesis, contains the cellular calcium stores that are an essential component of many signaling pathways, and is the proximal site of a signal transduction cascade that responds to cellular stress conditions and serves to maintain homeostasis of the cell. All eucaryotic cells possess an ER, which can comprise nearly 50% of the membranes of a cell. Its functions can be divided into those that occur on the cytosolic side of the membrane (where protein translation and signal transduction cascades occur) and the luminal space (where most other ER functions take place). Our studies during the past several years have revealed that the ER molecular chaperone BiP is a master regulator of ER function. It is responsible for maintaining the permeability barrier of the ER during protein translocation, directing protein folding and assembly, targeting misfolded proteins for retrograde translocation so they can be degraded by the proteasome, contributing to ER calcium stores, and sensing conditions of stress in this organelle, to activate the mammalian unfolded protein response.