The atypical cadherin flamingo links frizzled and Notch signaling in planar polarity establishment in the Drosophila eye
The atypical cadherin flamingo links frizzled and Notch signaling in planar polarity establishment in the Drosophila eye
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DOI：
10.1016/s1534-5807(02)00147-8
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发表时间：
2002-05-01
影响因子：
11.8
通讯作者：
Mlodzik, M
中科院分区：
文献类型：
--
作者：
Das, G;Reynolds-Kenneally, J;Mlodzik, M
平面细胞极性在果蝇眼睛中通过Fz和Notch信号的两层机制，通过光感受器R3和R4的不同命运规范来建立：Fz信号指定R3并诱导DI激活R4中的Notch。我们发现非典型钙粘蛋白火烈鸟（Fmi）在R3和R4中都起着关键但不同的作用。Fmi首先在R3/R4的赤道细胞边界富集，与Fz/Dsh正相互作用。随后，Fmi在R4中被Notch上调，并通过拮抗Fz信号下调DI表达。这反过来又放大和加强了R3/R4对中初始的fz信号偏置。我们的结果揭示了眼睛和翅膀之间的平面细胞极性遗传电路的差异。
Planar cell polarity is established in the Drosophila eye through distinct fate specification of photoreceptors R3 and R4 by a two-tiered mechanism employing Fz and Notch signaling: Fz signaling specifies R3 and induces DI to activate Notch in R4. We show that the atypical cadherin Flamingo (Fmi) plays critical, but distinct, roles in both R3 and R4. Fmi is first enriched at equatorial cell borders of R3/R4, positively interacting with Fz/Dsh. Subsequently, Fmi is upregulated in R4 by Notch and functions to downregulate DI expression by antagonizing Fz signaling. This in turn amplifies and enforces the initial Fz-signaling bias in the R3/R4 pair. Our results reveal differences in the planar cell polarity genetic circuitry between the eye and the wing.