The hippocampus and transverse patterning guided by olfactory cues
The hippocampus and transverse patterning guided by olfactory cues
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DOI：
10.1037/0735-7044.112.4.762
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发表时间：
1998-08-01
影响因子：
1.9
通讯作者：
Eichenbaum, H
中科院分区：
文献类型：
--
作者：
Dusek, JA;Eichenbaum, H
正常大鼠和海马系统损伤的大鼠接受了一种新颖的嗅觉版本的横向模式任务训练，该任务涉及同时学习和持续执行 3 个部分模糊的辨别问题（A+B-、B+C-、C+A-）。穹窿或周围内嗅皮质损伤的动物至少与正常大鼠一样快地获得这些问题，这些问题是在涉及相同刺激对的连续试验中出现的。当刺激对呈现的顺序是随机的时，所有组在初始测试中也表现良好。正常大鼠在额外的测试中继续进行适当的区分，试验以随机顺序呈现。相比之下，两组海马系统受损的人在持续随机顺序测试中表现不佳。这些结果将横向模式缺陷的普遍性扩展到嗅觉形态，并证明穹窿或鼻周-内嗅损伤后缺陷的程度相当。研究结果还表明，横向模式问题可以在没有关键海马参与的情况下短暂获得，尽管持续的表现依赖于海马功能。
Normal rats and rats with hippocampal system damage were trained on a novel, olfactory version of the transverse-patterning, task that involved the concurrent learning and continued performance of 3 partially ambiguous discrimination problems (A+B-, B+C-, C+A-). Animals with lesions of the fornix or perirkinal-entorhinal cortex acquired at least as rapidly as normal rats these problems presented in sequential blocks of trials involving the same stimulus pair. All groups also performed well on an initial test session when the order of stimulus pair presentations was randomized. Normal rats continued to discriminate appropriately in additional testing sessions with trials presented in random order. By contrast, both groups with hippocampal system damage performed poorly in continued random-order testing. These results extend the generality of the deficit in transverse patterning to the olfactory modality and demonstrate that the deficit is equivalent in magnitude after fornix or perirhinal-entorhinal damage. Findings also suggest that the transverse-patterning problem can be acquired transiently without critical hippocampal involvement, although continued performance relies on hippocampal function.