Temporally dimorphic recruitment of dopamine neurons into stress response circuitry in Drosophila.
Temporally dimorphic recruitment of dopamine neurons into stress response circuitry in Drosophila.
复制标题
果蝇应激反应回路中多巴胺神经元的时间二态性募集。
DOI：
10.1037/a0033602
复制
发表时间：
2013
影响因子：
1.9
通讯作者：
Neckameyer,WendiS
中科院分区：
文献类型：
--
作者：
Argue,KathrynJ;Neckameyer,WendiS
许多研究指出，在人的一生中，在不同的时间点容易受到压力和与压力相关的病理的影响。这些敏感窗口通常在神经发育时期，如胚胎发育、婴儿期和青春期。了解神经回路如何随着个体年龄的增长而改变，从而影响对压力的敏感性，这一点至关重要。在这里，我们比较了果蝇的两个阶段：性不成熟和性成熟。我们利用果蝇中可用的遗传资源，在性未成熟和成熟的动物中操纵突触前和突触后的多巴胺信号，然后分析它们的心率和运动行为，以应对饥饿和氧化应激。我们的结果表明，性未成熟和成熟动物在心率、高流动性时段、平均速度和其他几个运动行为参数的应激反应方面存在显著差异。我们的数据显示，对于性不成熟和成熟的个体，多巴胺神经元被不同地招募到应激反应电路中。通过观察以前在哺乳动物模型中显示的受应激影响的行为，以及在情感障碍模型中改变的行为，我们为性成熟期间应激反应回路的发展和维护提供了一个遗传上易于处理的模型。(心理信息数据库记录(C)2016 APA，版权所有)
Many studies have pointed to vulnerability to stress and stress-related pathologies at different timepoints during an individual’s life span. These sensitive windows are usually during periods of neural development, such as embryogenesis, infancy, and adolescence. It is critical to understand how neural circuitry may change as an individual ages in ways that could affect susceptibility to stress. Here we compare two stages in Drosophila melanogaster: sexual immaturity and sexual maturity. We used the genetic resources available in Drosophila to manipulate pre-and postsynaptic dopamine signaling in sexually immature and mature animals that were then assayed for heart rate and locomotor behavior in response to starvation and oxidative stress. Our results show significant differences in the stress response for sexually immature and mature animals for heart rate, periods of high mobility, mean velocity, and several other parameters of locomotor behavior. Our data show that dopamine neurons are differentially recruited into the stress response circuitry for sexually immature and mature individuals. By observing behaviors that have been previously shown in mammalian models to be affected by stress and altered in models of affective disorders, we provide a genetically tractable model for development and maintenance of the stress response circuitry during sexual maturation.(PsycINFO Database Record (c) 2016 APA, all rights reserved)