Stromal architecture and periductal decorin are potential prognostic markers for ipsilateral locoregional recurrence in ductal carcinoma in situ of the breast
Stromal architecture and periductal decorin are potential prognostic markers for ipsilateral locoregional recurrence in ductal carcinoma in situ of the breast
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DOI：
10.1111/his.12188
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发表时间：
2013-10-01
期刊：
影响因子：
6.4
通讯作者：
Libbrecht, Louis
中科院分区：
文献类型：
--
作者：
Van Bockstal, Mieke;Lambein, Kathleen;Libbrecht, Louis
目的自从引入筛查性乳房X光检查以来，导管原位癌（DCIS）的发病率有所增加。复发预测仍然不准确，可以通过识别其他预后标志物来改进。导管周围基质积极参与早期乳腺癌的进展。因此，本研究的目的是探讨 DCIS 中基质特征的预后潜力。方法和结果对第一组 65 例 DCIS 患者的组织病理学特征和激素受体/HER2 状态进行了分析，中位随访时间为 112 个月。 Cox回归分析显示，粘液样间质结构与同侧局部区域复发率增加显着相关（P=0.015）。接下来，我们对第二组 82 例 DCIS 病例中的 9 种基质蛋白进行了免疫组织化学筛查，并将它们的表达与基质结构相关联。因为基质核心蛋白聚糖表达减少与粘液样基质相关性最强（P
AimsThe incidence of ductal carcinoma insitu (DCIS) has increased since the introduction of screening mammography. Recurrence prediction is still not accurate, and could be improved by identifying additional prognostic markers. Periductal stroma actively participates in early breast cancer progression. Therefore, the aim of this study was to explore the prognostic potential of stromal characteristics in DCIS.Methods and resultsHistopathological features and hormone receptor/HER2 status were analysed in a first cohort of 65 cases of DCIS with a median follow-up of 112months. Cox regression analysis revealed that myxoid stromal architecture was significantly associated with increased ipsilateral locoregional recurrence (P=0.015). Next, we performed immunohistochemical screening of nine stromal proteins in a second cohort of 82 DCIS cases, and correlated their expression with stromal architecture. Because reduced stromal decorin expression correlated most strongly with myxoid stroma (P