Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy
Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy
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DOI：
10.1007/s00417-011-1620-1
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发表时间：
2011-08-01
影响因子：
2.7
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
--
作者：
Koizumi, Hideki;Yamagishi, Tetsuya;Kinoshita, Shigeru
应用增强型深度成像光学相干断层扫描技术（enhanced depth imaging optical coherence tomography，OCT）对44例（12女32男）典型的年龄相关性黄斑变性（age-related macular degeneration，AMD）和息肉状脉络膜血管病变（polypoidal choroidal vasculopathy，PCV）患者的黄斑中心凹下脉络膜厚度进行了研究。对44只患眼中的21只眼诊断为典型AMD，23只眼诊断为PCV，回顾性分析黄斑中心凹下脉络膜厚度。典型AMD（245 μ m）和PCV（293 μ m）患者之间的中心凹下脉络膜厚度差异具有统计学意义，即使在调整了年龄、等效球镜和性别分布后（P = 0.045）。与中心凹下脉络膜厚度小于300 μ m的患眼相比，中心凹下脉络膜厚度大于或等于300 μ m的患眼PCV的可能性高5.6倍（校正比值比5.60，95%可信区间1.30-24.0，P = 0.021）。这一结果表明，PCV中所见的脉络膜血管病变可能不仅仅是脉络膜新生血管伴随着边缘处的囊状毛细血管扩张，而是与典型AMD相比，脉络膜中可能具有显著的结构差异。
To investigate the subfoveal choroidal thickness in eyes with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), using enhanced depth imaging optical coherence tomography.Retrospective observational case series of 44 eyes of 44 patients (12 females and 32 males) with typical AMD or PCV located in the subfoveal region. Cross-sectional images of the choroid of each of the involved eyes were obtained by a spectral-domain OCT. The choroidal thickness under the fovea was retrospectively studied.Of the 44 eyes involved in this study, 21 eyes were diagnosed as typical AMD and the other 23 eyes were diagnosed as PCV. The difference in subfoveal choroidal thickness between the eyes with typical AMD (245 mu m) and those with PCV (293 mu m) was statistically significant, even after adjusting for age, spherical equivalent, and gender distribution (P = 0.045). When compared to eyes with subfoveal choroidal thickness less than 300 mu m, those with subfoveal choroidal thickness of 300 mu m or more were 5.6 times more likely to have PCV (adjusted odds ratio 5.60, 95% confidence interval 1.30-24.0, P = 0.021).The choroid under the fovea was thicker in eyes with PCV than those with typical AMD. This result suggests that the choroidal vascular lesion seen in PCV may not be just the choroidal neovascularization accompanied by saccular capillary dilations at the border, but may have a significant structural difference in the choroid compared to typical AMD.