Distribution of CB2 Cannabinoid Receptor in Adult Rat Retina
Distribution of CB2 Cannabinoid Receptor in Adult Rat Retina
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DOI：
10.1002/syn.20856
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发表时间：
2011-05-01
期刊：
影响因子：
2.3
通讯作者：
Lopez-Costa, Juan J.
中科院分区：
文献类型：
--
作者：
Lopez, Ester M.;Tagliaferro, Patricia;Lopez-Costa, Juan J.
大麻素的作用通过两种受体CB 1和CB 2介导。据报道，在视网膜中，CB 1存在于双极细胞、GABA能无长突细胞、水平细胞和内丛状层中。RT-PCR显示CB 2受体mRNA定位于光感受器、内核层和神经节细胞层。本工作的目的是用免疫细胞化学方法定位大鼠视网膜中的CB 2受体。结果表明，CB_2受体定位于视网膜色素上皮细胞、内感光节段、水平细胞和无长突细胞、节细胞层细胞和内丛状层纤维。这些结果与RT-PCR的研究结果一致，并提供了一些额外的信息，CB 2受体的分布。需要进一步的研究来阐明这种大麻素受体在视网膜中的作用。Synapse 65：388-392，2011.（C）2010 Wiley-Liss，Inc.
Cannabinoid effects are mediated through two receptors, CB1 and CB2. In the retina CB1 has been reported in bipolar cells, gabaergic amacrine cells, horizontal cells, and inner plexiform layer. CB2 receptor mRNA localization was shown in photoreceptors, inner nuclear layer, and ganglion cell layer by using RT-PCR. The aim of this work was to localize CB2 receptor in the rat retina by using immunocytochemistry. Our results showed that CB2 receptor was localized in retinal pigmentary epithelium, inner photoreceptor segments, horizontal and amacrine cells, cells localized in ganglion cell layer, and in fibers of inner plexiform layer. These results are in agreement with studies using RT-PCR and provide some additional information about the distribution of CB2 receptor. Further studies are needed to clarify the role of this cannabinoid receptor in the retina. Synapse 65: 388-392, 2011. (C)2010 Wiley-Liss, Inc.