MATERNAL ZINC, IRON, FOLIC-ACID, AND PROTEIN NUTRITURE AND OUTCOME OF HUMAN-PREGNANCY
MATERNAL ZINC, IRON, FOLIC-ACID, AND PROTEIN NUTRITURE AND OUTCOME OF HUMAN-PREGNANCY
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DOI：
10.1093/ajcn/40.3.496
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发表时间：
1984-01-01
影响因子：
7.1
通讯作者：
STELLING, HP
中科院分区：
文献类型：
--
作者：
MUKHERJEE, MD;SANDSTEAD, HH;STELLING, HP
妇女（450）在怀孕期间和产后进行了观察。评估了包括12项母体营养状况实验室指标在内的13个变量。胎儿体重和头围的变异分别为9.9%和8.1%，可通过母体营养实验室指标的多项式逐步回归预测。母体血浆锌水平与胎儿体重呈负相关。比较孕妇血浆锌、白蛋白、铁和叶酸水平最高和最低四分位数的妊娠并发症发生率。仅使用来自妊娠期被精确识别的初始血液样本的数据（n = 394），在最低四分位数中发现母胎并发症的总发生率与锌和白蛋白水平之间存在显著相关性（锌，P < 0.02;白蛋白，P < 0.02）。低锌或低白蛋白也与胎儿窘迫的特殊并发症有关（锌，P < 0.002;白蛋白P < 0.02）。高叶酸水平与并发症发生率（P < 0.008）和胎儿窘迫发生率（P < 0.002）有关。当所有的数据（n = 713），包括重复的血液样本和数据，从56个母亲的三个月不能被精确地验证进行了评估，其他并发症和最低四分位数锌和白蛋白和最高四分位数叶酸之间的关联进行了鉴定。对初始血液样本数据的判别分析显示，血浆锌仅在血浆锌含量最低四分位数的女性中是胎儿母体并发症的鉴别因素。
Women (450) were observed during pregnancy and postpartum. Variables (13) including 12 laboratory indices of maternal nutrient status were assessed. Of the variance in fetal weight and head circumference 9.9 and 8.1%, respectively, were predictable by polynomial stepwise regression of laboratory indices of maternal nutrition. Maternal plasma Zn levels were inversely correlated with fetal weight. The occurrence of pregnancy complications in the highest and lowest quartiles of maternal plasma Zn, albumin, iron and folic acid were compared. Using data only from the initial blood samples for which the trimester was identified precisely (n = 394), a significant association was found between the total occurrence of fetomaternal complications and Zn and albumin levels in the lowest quartile (Zn, P < 0.02; albumin, P < 0.02). Low Zn or low albumin were also associated with the specific complications of fetal distress (Zn, P < 0.002; albumin P < 0.02). high plasma folate was also associated with the total occurrence of complications (P < 0.008) and with fetal distress (P < 0.002). When all data (n = 713) including repeat blood samples and data from 56 mothers in whom the trimester could not be verified precisely were evaluated, associations between other complications and lowest quartile Zn and albumin and highest quartile folate were identified. Discriminant analysis of data from the initial blood samples revealed that plasma Zn was a discriminator for fetomaternal complications only in women in the lowest quartile for plasma Zn.