Terahertz reflectometry of burn wounds in a rat model.
Terahertz reflectometry of burn wounds in a rat model.
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DOI：
10.1364/boe.2.002339
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发表时间：
2011-08-01
影响因子：
3.4
通讯作者：
Mourad PD
中科院分区：
文献类型：
--
作者：
Arbab MH;Dickey TC;Winebrenner DP;Chen A;Klein MB;Mourad PD
我们目前的亚毫米波反射的实验大鼠皮肤烧伤模型获得的太赫兹时域光谱（THz-TDS）技术。在实验前即刻安乐死的大鼠（n = 4）上产生全层烧伤（经组织学证实）。统计分析表明，烧伤组织在0.5和0.7 THz之间的频率范围内表现出比正常皮肤更高的反射率（p < 0.05），这可能是由于烧伤后间质水肿的形成。此外，我们证明了一个双德拜介电弛豫模型可以用来解释正常和不太严重烧伤大鼠皮肤的太赫兹响应。最后，我们的数据表明，实验烧伤测量值和正常皮肤模型之间的构象程度可能被用来推断烧伤的严重程度。
We present sub-millimeter wave reflectometry of an experimental rat skin burn model obtained by the Terahertz Time-Domain Spectroscopy (THz-TDS) technique. Full thickness burns, as confirmed by histology, were created on rats (n = 4) euthanized immediately prior to the experiments. Statistical analysis shows that the burned tissue exhibits higher reflectivity compared to normal skin over a frequency range between 0.5 and 0.7 THz (p < 0.05), likely due to post-burn formation of interstitial edema. Furthermore, we demonstrate that a double Debye dielectric relaxation model can be used to explain the terahertz response of both normal and less severely burned rat skin. Finally, our data suggest that the degree of conformation between the experimental burn measurements and the model for normal skin can potentially be used to infer the extent of burn severity.