First examples of improved catalytic asymmetric C-C bond formation using the monodentate ligand combination approach
First examples of improved catalytic asymmetric C-C bond formation using the monodentate ligand combination approach
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DOI：
10.1021/ol035106o
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发表时间：
2003-08-21
期刊：
影响因子：
5.2
通讯作者：
Feringa, BL
中科院分区：
文献类型：
--
作者：
Duursma, A;Hoen, R;Feringa, BL
在铑催化的硼酸与三种不同底物的共轭加成反应中，使用手性单齿亚磷酰胺配体的组合，我们首次证明了配体组合方法适用于C-C键的形成。发现基于配体的杂组合的手性催化剂比均组合的手性催化剂更有效。P-31 NMR实验表明，形成的杂组合超过同质组合。
Using a combination of chiral monodentate phosphoramidite ligands in the rhodium-catalyzed conjugate addition of boronic acids to three different substrates, we have shown for the first time that the ligand combination approach is applicable for C-C bond formation. Chiral catalysts based on hetero-combinations of ligands are found to be more effective than the homo-combinations. P-31 NMR experiments show that the hetero-combinations are formed in excess over the homo-combinations.