Correlation between survivin expression and locoregional control in cervical squamous cell carcinomas treated with radiation therapy.
Correlation between survivin expression and locoregional control in cervical squamous cell carcinomas treated with radiation therapy.
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DOI：
10.1016/j.ygyno.2006.10.005
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发表时间：
2007-03
影响因子：
4.7
通讯作者：
Yoshiyuki Suzuki;K. Oka;D. Yoshida;K. Shirai;T. Ohno;S. Kato;H. Tsujii;T. Nakano
中科院分区：
文献类型：
--
作者：
Yoshiyuki Suzuki;K. Oka;D. Yoshida;K. Shirai;T. Ohno;S. Kato;H. Tsujii;T. Nakano
目的Survivin是细胞凋亡抑制因子中的一员，参与调节细胞分裂和抑制细胞凋亡。在许多恶性肿瘤中，胞浆Survivin的过度表达与预后不良有关。然而，Survivin核表达的预后价值仍不明确。在此，我们探讨Survivin在宫颈癌放射治疗中的预后价值。方法收集72例单纯放射治疗的宫颈鳞癌标本。用免疫组织化学方法检测Survivin的表达水平，并评价细胞的阳性反应。结果14%(10/72)的组织标本胞核阳性率大于5%，47%(34/72)的组织胞浆阳性率大于50%。胞浆Survivin阴性肿瘤的局控率为94%，明显高于胞浆Survivin阳性肿瘤的76%(P=0.046)。Survivin核阳性和胞浆阴性患者的局部控制率为95%，显著高于其他患者的74%(P=0.02)。结论单纯胞浆Survivin表达及胞核和胞浆联合表达可作为宫颈鳞癌局部控制的预测指标。
OBJECTIVESurvivin is a member of the inhibitors of apoptosis and has been implicated in both the regulation of cell division and the suppression of apoptosis. Over-expression of cytoplasmic survivin correlates with an unfavorable prognosis in many malignant tumors. However, the prognostic value of nuclear survivin expression is still equivocal. Here, we investigated the prognostic value of survivin expression in cervical cancer treated with radiation therapy.METHODSTissue sections were obtained from 72 patients with cervical squamous cell carcinoma treated with radiation therapy alone. Survivin expression levels were determined by immunohistochemical staining and evaluated for cell positivity. The correlation between survivin expression and clinical outcome endpoints including cause-specific survival and local control were evaluated.RESULTSA total of 14% (10/72) of tissue specimens had greater than 5% nucleus positivity, while 47% (34/72) had greater than 50% cytoplasmic positivity. Local control rate of the cytoplasmic survivin-negative tumors was 94%, significantly higher than the 76% of the positive tumors (p=0.046). Local control rate of the nuclear survivin-positive and cytoplasmic survivin-negative patients was 95%, significantly higher than the 74% of the other patients (p=0.02). In contrast, no significant correlation was noted between survivin expression and disease-free survival.CONCLUSIONSThe cytoplasmic survivin expression alone and the combination of nuclear and cytoplasmic expression were suggested to be predictors for local control in patients with cervical squamous cell carcinoma treated with radiation therapy alone.