Construction of Biocompatible Dual-Drug Loaded Complicated Nanoparticles for in vivo Improvement of Synergistic Chemotherapy in Esophageal Cancer
Construction of Biocompatible Dual-Drug Loaded Complicated Nanoparticles for in vivo Improvement of Synergistic Chemotherapy in Esophageal Cancer
复制标题
构建生物相容性双药负载复杂纳米粒子以改善食管癌体内协同化疗
DOI：
10.3389/fonc.2020.00622
复制
发表时间：
2020-05-05
影响因子：
4.7
通讯作者：
Zhang, Dexin
中科院分区：
文献类型：
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作者：
Zhan, Wenhua;Li, Hanrui;Zhang, Dexin
联合化疗是食管癌的常规治疗方法，但其毒副作用等缺点极大地限制了联合化疗的临床应用。为了克服这些缺点，我们开发了一种用于负载阿霉素和β-榄香烯的介孔二氧化硅纳米颗粒系统。将β-榄香烯包裹在介孔二氧化硅纳米粒的孔中，并通过透明质酸将阿霉素静电吸附在介孔二氧化硅纳米粒的表面，构建了双药协同纳米粒（bMED NPs，~77.15 nm）。体外研究表明，bMED纳米粒对食管癌细胞株具有良好的治疗效果。体内荧光成像结果表明，bMED纳米粒可以在肿瘤部位积聚，并实现体内长期循环和持续释药。此外，bMED纳米粒在食管癌小鼠模型中表现出显著的抗肿瘤作用，为食管癌化疗提供了良好的平台。
Combination chemotherapy is a routine treatment for esophageal cancer, but some shortcomings, such as drug toxicity and side effects, greatly limit the clinical application of combination therapy. To overcome these shortcomings, we have developed a mesoporous silica nanoparticle system that was used to load doxorubicin and β-elemene. β-elemene was encapsulated in the pore of mesoporous silica nanoparticle and doxorubicin was electrostatically adsorbed on the surface of mesoporous silica nanoparticle by hyaluronic acid to construct dual drugs synergistic nanoparticles (bMED NPs, ~77.15 nm). In vitro studies demonstrated that bMED NPs had a good treatment effect in esophageal cancer cell lines. In vivo fluorescence imaging results demonstrated that bMED NPs could accumulate in tumor sites and achieve in vivo long-term circulation and continuous drug release. In addition, bMED NPs exhibited significant antitumor effects in the esophageal cancer mouse model, which may provide a great platform for esophageal cancer chemotherapy.