Multiple Micronutrient Supplementation Using Spirulina platensis during the First 1000 Days is Positively Associated with Development in Children under Five Years: A Follow up of A Randomized Trial in Zambia
Multiple Micronutrient Supplementation Using Spirulina platensis during the First 1000 Days is Positively Associated with Development in Children under Five Years: A Follow up of A Randomized Trial in Zambia
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DOI：
10.3390/nu11040730
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发表时间：
2019-04-01
期刊：
影响因子：
5.9
通讯作者：
Chitundu, Maureen
中科院分区：
文献类型：
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作者：
Masuda, Kazuya;Chitundu, Maureen
儿童早期发育依赖于各种微量营养素。我们最近报道称，使用螺旋藻进行家庭强化辅食可缩短赞比亚婴儿达到运动里程碑的时间。本研究的目的是评估前 1000 天内补充螺旋藻与学龄前儿童粗大运动发育、精细运动发育、语言和个人社交技能之间的长期关联。我们使用了在赞比亚进行的一项随机试验的纵向数据。 2015 年，501 名婴儿（年龄为 6-18 个月）每天补充含螺旋藻（SP）和不含螺旋藻（CON）的玉米大豆粥。补充期持续16个月。 2018 年 1 月，对参与初次试验的儿童进行了重新调查（CON：182 名儿童；SP：188 名儿童；现年龄 36-48 个月）。我们使用马拉维发育评估工具的修改版本评估了婴儿的粗大运动发育、精细运动发育、语言和个人社交技能。初始临床试验注册号为NCT03523182。 SP 组的儿童在粗大和精细运动发育、语言和社交技能方面的得分高于 CON 组的儿童。在最初的 1000 天内使用螺旋藻进行家庭强化辅食改善了赞比亚学龄前儿童的发育。
Early childhood development relies on various micronutrients. We recently reported that home fortification of complementary foods using spirulina reduced the time to attain motor milestones in Zambian infants. The objective of this study is to estimate the long-term associations between spirulina supplementation during the first 1000 days and child gross motor development, fine motor development, language, and personal-social skills at preschool age. We used longitudinal data from a randomized trial conducted in Zambia. In 2015, 501 infants (age, 6-18 months) were provided daily supplements of maize-soy-based porridge with spirulina (SP) and without spirulina (CON). Supplementation period lasted for 16 months. In January 2018, children who participated in the initial trial were resurveyed (CON: 182 children; SP: 188 children; now aged 36-48 months). We assessed the infants' gross motor development, fine motor development, language, and personal-social skills using a modified version of Malawi Development Assessment Tool. The initial clinical trial registration number was NCT03523182. Children in the SP group had higher scores in gross and fine motor development, language, and social skills than those in the CON group. Home fortification of complementary foods using spirulina during the first 1000 days improved development among Zambian children at preschool age.