AGGRESSIVE VERSUS CONSERVATIVE MANAGEMENT OF STAGE-4 RENAL CELL-CARCINOMA
AGGRESSIVE VERSUS CONSERVATIVE MANAGEMENT OF STAGE-4 RENAL CELL-CARCINOMA
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DOI：
10.1016/s0022-5347(17)57959-8
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发表时间：
1977-01-01
影响因子：
6.6
通讯作者：
CERNY, JC
中科院分区：
文献类型：
--
作者：
KLUGO, RC;DETMERS, M;CERNY, JC
改善治疗转移性人肾细胞癌的方法将需要积极的手术和化疗方法。肾切除联合激素和非激素化疗可显著提高中位生存期和3年生存率。异种特异性免疫核糖核酸和卡介苗的使用提供了有希望的免疫治疗方式，可以与手术和化疗方案相结合。转移性疾病的早期诊断对于正确评估各种治疗方式的结果以及可能提高这些治疗方式的效率是重要的。孤立性转移结节的处理应包括积极切除原发和转移结节。在疾病的所有阶段都应考虑辅助性激素和非激素化疗。
Improved modalities to treat metastatic human renal cell carcinoma will require an aggressive surgical and chemotherapeutic approach. Nephrectomy with hormonal and nonhormonal chemotherapy improves median survival and 3 yr survival significantly. The use of xenogeneic specific immune RNA and BCG offers promising immunotherapeutic modalities that may be combined with surgical and chemotherapeutic regimens. Early diagnosis of metastatic disease is important to evaluate properly the results of various modalities of treatment and possibly to improve the efficiency of these modalities. The management of solitary metastatic nodules should involve aggressive resection of the primary and metastatic nodule. Adjuvant hormonal and nonhormonal chemotherapy should be considered in all stages of the disease.