The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys
The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys
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腹侧纹状体是猴子脊髓损伤后手指灵活性功能恢复的关键节点
DOI：
10.1093/cercor/bhz307
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发表时间：
2019
期刊：
影响因子：
3.7
通讯作者：
Nishimura Yukio
中科院分区：
文献类型：
--
作者：
Suzuki Michiaki;Onoe Kayo;Sawada Masahiro;Takahashi Nobuaki;Higo Noriyuki;Murata Yumi;Tsukada Hideo;Isa Tadashi;Onoe Hirotaka;Nishimura Yukio
在最近的一项研究中，我们证实在脊髓损伤(SCI)后的早期恢复阶段，腹侧纹状体(VST)直接控制手指的运动，暗示VST可能是负责手指灵巧运动恢复的神经底物的一部分。VST被广泛认为是动机的关键节点，但并不被认为与肢体运动的直接控制有关。因此，VST与脊髓损伤后运动恢复之间是否存在因果关系尚不清楚，VST在脊髓损伤后灵活手指运动或一般手指运动恢复中的作用尚不清楚。在本研究中，脊髓损伤猕猴模型的脑功能成像显示，在精确握力的恢复过程中，运动相关区域与VST之间的功能连接增强，但不是脊髓损伤后的整个手指握力。此外，VST的永久性损伤阻碍了精确握力的恢复，但不妨碍粗握的恢复。因此，VST对于灵巧手指运动的功能恢复是特别需要的。这些结果表明，VST是手指灵巧功能恢复所需的皮质重组的关键节点。
In a recent study, we demonstrated that the ventral striatum (VSt) controls finger movements directly during the early recovery stage after spinal cord injury (SCI), implying that the VSt may be a part of neural substrates responsible for the recovery of dexterous finger movements. The VSt is accepted widely as a key node for motivation, but is not thought to be involved in the direct control of limb movements. Therefore, whether a causal relationship exists between the VSt and motor recovery after SCI is unknown, and the role of the VSt in the recovery of dexterous finger movements orfinger movements in general after SCI remains unclear. In the present study, functional brain imaging in a macaque model of SCI revealed a strengthened functional connectivity between motor-related areas and the VSt during the recovery process for precision grip, but not whole finger grip after SCI. Furthermore, permanent lesion of the VSt impeded the recoveryof precision grip, but not coarse grip. Thus, the VSt was needed specifically for functional recovery of dexterous finger movements. These results suggest that the VSt is the key node of the cortical reorganization required for functional recovery of finger dexterity.