Mechanotransduction: Forcing a change in metabolism.
Mechanotransduction: Forcing a change in metabolism.
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DOI：
10.1016/j.ceb.2023.102219
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发表时间：
2023-08
影响因子：
7.5
通讯作者：
Logan W. Dawson;Nicholas M. Cronin;K. DeMali
中科院分区：
文献类型：
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作者：
Logan W. Dawson;Nicholas M. Cronin;K. DeMali
上皮细胞和内皮细胞在其一生中经历许多机械信号。细胞通过强化细胞骨架网络和粘附来抵抗这些力。这种加固在能量上是昂贵的。在这里，我们描述如何满足这些充满活力的需求。我们专注于上皮细胞和内皮细胞对机械信号的反应，描述上皮细胞和内皮细胞的能量需求，并确定这些细胞用于增加糖酵解，氧化磷酸化和脂肪酸代谢的机制。我们讨论了两种细胞类型的反应的相似性和差异。
Epithelial and endothelial cells experience numerous mechanical cues throughout their lifetimes. Cells resist these forces by fortifying their cytoskeletal networks and adhesions. This reinforcement is energetically costly. Here we describe how these energetic demands are met. We focus on the response of epithelial and endothelial cells to mechanical cues, describe the energetic needs of epithelia and endothelia, and identify the mechanisms these cells employ to increase glycolysis, oxidative phosphorylation, and fatty acid metabolism. We discuss the similarities and differences in the responses of the two cell types.