Plant viruses and bacteriophages for drug delivery in medicine and biotechnology.
Plant viruses and bacteriophages for drug delivery in medicine and biotechnology.
复制标题
DOI：
10.1016/j.cbpa.2017.03.013
复制
发表时间：
2017-06
影响因子：
7.8
通讯作者：
Steinmetz NF
中科院分区：
文献类型：
--
作者：
Czapar AE;Steinmetz NF
有各种各样的合成和天然存在的纳米材料正在开发中的纳米级货物交付应用。病毒在这些发展中发挥着特殊的作用，因为它们可以被视为天然存在的纳米材料，用于包装和运送货物。虽然任何纳米材料都有其优点和缺点，但病毒纳米颗粒（VNPs），特别是来自植物病毒和噬菌体的病毒纳米颗粒，是用于货物递送的有吸引力的选择，因为它们是生物相容的，可生物降解的，并且对哺乳动物无感染性。它们基于蛋白质的结构通常以原子分辨率理解，并且可以通过化学和基因工程以原子级精度进行修改。在这里，我们提出了针对人类健康和农业应用的植物病毒和噬菌体的新兴技术发展的重点审查。发展的关键目标领域是它们在化学疗法、光动力疗法、农药递送、基因疗法、疫苗载体和免疫疗法中的用途。
There are a wide variety of synthetic and naturally occurring nanomaterials under development for nanoscale cargo-delivery applications. Viruses play a special role in these developments, because they can be regarded as naturally occurring nanomaterials evolved to package and deliver cargos. While any nanomaterial has its advantage and disadvantages, viral nanoparticles (VNPs), in particular the ones derived from plant viruses and bacteriophages, are attractive options for cargo-delivery as they are biocompatible, biodegradable, and non-infectious to mammals. Their protein-based structures are often understood at atomic resolution and are amenable to modification with atomic-level precision through chemical and genetic engineering. Here we present a focused review of the emerging technology development of plant viruses and bacteriophages targeting human health and agricultural applications. Key target areas of development are their use in chemotherapy-, photodynamic therapy-, pesticide-delivery, gene therapy, vaccine carriers, and immunotherapy.