TIGRFAMs: a protein family resource for the functional identification of proteins
TIGRFAMs: a protein family resource for the functional identification of proteins
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DOI：
10.1093/nar/29.1.41
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发表时间：
2001-01-01
影响因子：
14.9
通讯作者：
White, O
中科院分区：
文献类型：
--
作者：
Haft, DH;Loftus, BJ;White, O
TIGRFAM是一个蛋白质家族的集合，其特征在于策划的多序列比对，隐马尔可夫模型和相关信息，旨在支持通过序列同源性进行蛋白质的自动功能鉴定。我们引入术语“equivalog”来描述一组同源蛋白质的成员，这些同源蛋白质自它们最后的共同祖先以来在功能上是保守的。在可能的情况下，相关蛋白质被分组到等价家族中，否则被分组到具有其他分级定义的同源类型的蛋白质家族中。TIGRFAM目前包含超过800个蛋白质家族，可在www.tigr.org/TIGRFAMs搜索或下载。在可实现的情况下，通过等价家族分类补充了通过直系、超家族、域或基序分类。它提供了最适合于大规模基因组测序项目中蛋白质特定功能自动分配的信息。
TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term 'equivalog' to describe members of a set of homologous proteins that are conserved with respect to function since their last common ancestor. Related proteins are grouped into equivalog families where possible, and otherwise into protein families with other hierarchically defined homology types. TIGRFAMs currently contains over 800 protein families, available for searching or downloading at www.tigr.org/TIGRFAMs. Classification by equivalog family, where achievable, complements classification by orthology, superfamily, domain or motif. It provides the information best suited for automatic assignment of specific functions to proteins from large-scale genome sequencing projects.