Prostaglandin transport
Prostaglandin transport
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DOI：
10.1016/s0090-6980(02)00061-8
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发表时间：
2002-08-01
影响因子：
2.9
通讯作者：
Schuster, VL
中科院分区：
文献类型：
--
作者：
Schuster, VL
新合成的前列腺素（PGs）通过简单扩散从细胞流出，由pH和膜电位驱动。代谢清除需要跨质膜的能量依赖性摄取，然后是细胞质氧化。一些PG载体已被克隆和表征。PGT广泛表达于环氧合酶（考克斯）阳性细胞中，似乎是乳酸/PG交换器，并且与考克斯协同调节。与神经递质释放和再摄取类似，PGT可通过再摄取调节细胞周围PG水平。PGT还可以引导PG朝向和/或远离特定组的PG受体。OATP转运蛋白家族的其他成员也催化PG摄取;这些被重复表达并且对PG具有可变的亲和力。OAT是接受PG的α-酮戊二酸/有机阴离子交换剂;这些可能代表肾脏和肝脏PG降解和排泄中的摄取步骤。最后，某些谷胱甘肽结合的白三烯和PG被MRP从细胞中主动挤出;这些也可能在PG的代谢清除中发挥作用。(C)2002年爱思唯尔科学公司All rights reserved.
Newly synthesized prostaglandins (PGs) efflux from cells by simple diffusion, driven by pH and the membrane potential. Metabolic clearance requires energy-dependent uptake across the plasma membrane, followed by cytoplasmic oxidation. Several PG carriers have been cloned and characterized. PGT is broadly expressed in cyclooxygenase (COX)-positive cells, appears to be a lactate/PG exchanger, and is coordinately regulated with COX. By analogy with neurotransmitter release and re-uptake, PGT may regulate pericellular PG levels via re-uptake. PGT may also direct PGs towards and/or away from specific sets of PG receptors. Other members of the OATP transporter family also catalyze PG uptake; these are variably expressed and have variable affinities for PGs. The OATs are alpha-ketoglutarate/organic anion exchangers that accept PGs; these probably represent the uptake step in renal and hepatic PG degradation and excretion. Finally, certain glutathione-conjugated leukotrienes and PGs are actively extruded from cells by the MRPs; these may also play a role in metabolic clearance of PGs. (C) 2002 Elsevier Science Inc. All rights reserved.