A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.
A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.
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一种来自 Monchaetum vulcanicum 的新乌苏烷三萜，可抑制 DNA 聚合酶 β 裂合酶。
DOI：
10.1021/np030531b
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Kingston,DavidGI
中科院分区：
文献类型：
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作者：
Chaturvedula,VSPrakash;Gao,Zhijie;Jones,ShannonH;Feng,Xizhi;Hecht,SidneyM;Kingston,DavidGI
生测分离得到一个新的三萜类化合物(1)和4个已知化合物：熊果酸(2)、2-α-羟基熊果酸(3)、3-(p-香豆酰基)熊果酸(4)和β-谷甾基-β-d-半乳糖苷(5)。通过广泛的一维和二维核磁共振波谱解释和化学衍生化，确定了新化合物1的结构为3-β-乙酰氧基-2-α-羟基-12-烯-28-酸。化合物1、−3和5具有聚合酶β裂解酶活性。
Bioassay-directed fractionation of a butanone extract ofMonochaetumvulcanicumresulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2α-hydroxyursolic acid (3), 3-(p-coumaroyl)ursolic acid (4), and β-sitosteryl-β-d-galactoside (5). The structure of the new compound1was established as 3β-acetoxy-2α-hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds1−3and5exhibited polymerase β lyase activity.