Motor function of the opossum sphincter of Oddi.
Motor function of the opossum sphincter of Oddi.
复制标题
负鼠奥迪括约肌的运动功能。
DOI：
10.1172/jci110761
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Arndorfer,RC
中科院分区：
文献类型：
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作者：
Toouli,J;Dodds,WJ;Honda,R;Sarna,S;Hogan,WJ;Komarowski,RA;Linehan,JH;Arndorfer,RC
我们研究了负鼠Oddi （SO）的括约肌，因为在这个物种中，SO的长度约为3厘米，它的腹外位置允许记录运动活动，而十二指肠运动活动的干扰可以忽略不计。120只动物的SO段通过以下一种或多种方法进行评估：(a)腔内压力测定；(b)肌电图;(c)用点滴计数器监测胆总管（CBD）流量；(d)导管内造影剂放射照相；(e)组织学检查。使用直径0.6 mm的输注导管进行SO牵引时，在SO节段末端4-5 mm处总是显示18 +/- 3 SE mm Hg的高压区（HPZ）。该HPZ管腔狭窄，直径0.5-0.7 mm，圆形肌肉突出。终端SO中的HPZ既有有源成分，也有无源成分。在SO段与CBD和胰管交界处，不稳定地出现振幅最小的HPZ和下层平滑肌的缺乏。索段的主要特征是有节奏的蠕动收缩，起源于索近端，并向十二指肠传播。这些收缩以2-8次/分钟的速率自发发生，幅度可达200毫米汞柱，持续时间约5秒，不被河豚毒素消除。同时进行的肌电和压力测量记录显示，每次相性收缩之前都会立即出现电尖峰爆发。造影、造影剂CBD流入、SO测压和SO肌电图同时记录显示，节律性蠕动收缩将造影剂从SO剥离到十二指肠。在SO收缩期间，CBD排空短暂中断，而SO充盈发生在SO蠕动收缩之间的舒张期。SO扩张增加了SO蠕动的频率。我们得出结论：(a)负鼠SO的主要特征是有节奏的蠕动收缩，起源于近端SO并向十二指肠传播；(b)这些强力的SO蠕动收缩起源于肌源性，并作为蠕动泵，主动排空SO段；(c)在SO舒张期被动发生CBD流出，但在每次SO蠕动收缩时短暂中断；(d)在远端SO段存在一个具有有源和无源成分的短HPZ，并作为SO流出的可变电阻。图片
We studied the opossum sphincter of Oddi (SO) because in this species the SO is approximately 3 cm in length and its extraduodenal location permits recording of motor activity with negligible interference from duodenal motor activity. The SO segment of 120 animals was evaluated by one or more of the following: (a) intraluminal manometry; (b) electromyography; (c) common bile duct (CBD) flow monitored by a drop counter; (d) cineradiography of intraductal contrast medium; and (e) histologic examination. SO pull-throughs using an infused catheter of 0.6-mm o.d. invariably showed a high pressure zone (HPZ) of 18 +/- 3 SE mm Hg in the terminal 4-5 mm of the SO segment. This HPZ had a narrow lumen, 0.5-0.7 mm in diam, and prominent circular muscle. The HPZ in the terminal SO had both active and passive components. HPZ with minimal amplitude and a paucity of underlying smooth muscle were present inconstantly at the junction of the SO segment with the CBD and pancreatic duct, respectively. The dominant feature of the SO segment was rhythmic peristaltic contractions that originated in the proximal SO and propagated toward the duodenum. These contractions occurred spontaneously at a rate of 2-8/min, ranged up to 200 mm Hg in magnitude, had a duration of approximately 5 s and were not abolished by tetrodotoxin. Concurrent myoelectric and manometric recordings showed that each phasic contraction was immediately preceded by an electrical spike burst. Simultaneous recordings of cineradiography, CBD inflow of contrast medium, SO manometry, and SO electromyography indicated that rhythmic peristaltic contractions stripped contrast medium from the SO into the duodenum. During SO systole, CBD emptying was transiently interrupted, whereas SO filling occurred during the diastolic interval between SO peristaltic contractions. SO distention increased the frequency of SO peristalsis. We conclude that (a) the dominant feature of the opossum SO is rhythmic peristaltic contractions that originate in the proximal SO and propagate toward the duodenum; (b) these forceful SO peristaltic contractions are myogenic in origin and serve as a peristaltic pump that actively empties the SO segment; (c) CBD outflow occurs passively during SO diastole, but is interrupted transiently during each SO peristaltic contraction; and (d) a short HPZ with active as well as passive components exists in the distal SO segment and acts as a variable resistor to SO outflow.Images